Transdermal Delivery of Captopril and Metoprolol Tartrate with Microneedles

Nguyen, Kathy T.; Ita, Kevin; Parikh, Sanjai J.; Popova, Inna E.; Bair, Daniel A.

doi:10.2174/2210303104666141001003127

Cited by 19 publications

(20 citation statements)

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“…In another study, we used stainless steel microneedle arrays (750 μm) made by Microneedle Systems ® to facilitate the delivery of captopril and metoprolol tartrate across porcine skin. We studied the influence of MN rollers on the diffusion of these drugs [ 32 ]. In vitro diffusion studies were carried out using vertical Franz diffusion cells.…”

Section: Solid Microneedlesmentioning

confidence: 99%

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

2015

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Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving. There are also hydrogel-forming microneedles. A special attention is paid to hydrogel-forming microneedles. These are innovative microneedles which do not contain drugs but imbibe interstitial fluid to form continuous conduits between dermal microcirculation and an attached patch-type reservoir. Several microneedles approved by regulatory authorities for clinical use are also examined. The last part of this review discusses concerns and challenges regarding microneedle use.

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Section: Solid Microneedlesmentioning

confidence: 99%

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

2015

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“…Metal microneedles can be made from different metals including stainless steel [17,38,39] (Fig. 3) and titanium [40e43].…”

Section: Metal Microneedlesmentioning

confidence: 99%

“…Twelve passes of a goldetitanium microneedle roller resulted in a transdermal flux of 1.65 ng/cm 2 /hr for atenolol. Nguyen et al studied the effect of stainless steel microneedle arrays and rollers on transcutaneous flux of captopril and metoprolol tartrate across full thickness porcine skin [39]. The authors found that transdermal flux values for captopril and metoprolol tartrate increased from 75.04 mg/cm 2 /hr to 608.2 mg/ cm 2 /hr and 62.28 mg/cm 2 /hr to 290.93 mg/cm 2 /h respectively following the use of microneedle arrays.…”

Section: Metal Microneedlesmentioning

confidence: 99%

Transdermal delivery of drugs with microneedles: Strategies and outcomes

Ita

2015

Journal of Drug Delivery Science and Technology

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“…These devices are capable of facilitating the delivery of drugs across the skin by creating micron-sized pores through the stratum corneum without causing pain or bleeding [16]. The unique structure and geometry of microneedles influence the rate at which drugs diffuse through the skin.…”

Section: Introductionmentioning

confidence: 99%

“…The unique structure and geometry of microneedles influence the rate at which drugs diffuse through the skin. These factors include needle length, density, shape, and size in addition to the number of applications and the concentration of drug used [16,17]. The needles must be strong enough to penetrate the tough skin barrier while withstanding the pressure required during insertion [18].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

et al. 2016

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The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an Agilent 1200 Series HPLC system coupled to an Agilent G1969A TOF-MS system. Transdermal flux values of the drugs were determined from the steady-state portion of the cumulative amount versus time curves. Following twelve hours of microneedle roller application, there was a 6.74-fold increase in the percutaneous penetration of tiagabine hydrochloride (86.42 ± 25.66 µg/cm2/h) compared to passive delivery (12.83 ± 6.30 µg/cm2/h). For carbamazepine in 20% ethanol, passive transdermal flux of 7.85 ± 0.60 µg/cm2/h was observed compared to 10.85 ± 0.11 µg/cm2/h after microneedle treatment. Carbamazepine reconstituted in 30% ethanol resulted in only a 1.19-fold increase in drug permeation across porcine skin (36.73 ± 1.83 µg/cm2/h versus 30.74 ± 1.32 µg/cm2/h). Differences in flux values of untreated and microneedle-treated porcine skin using solid microneedles for the transdermal delivery of tiagabine were statistically significant. Although there were 1.38- and 1.19-fold increases in transdermal flux values of carbamazepine when applied as 20% and 30% ethanol solutions across microneedle-treated porcine skin, respectively, the increases were not statistically significant.

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Transdermal Delivery of Captopril and Metoprolol Tartrate with Microneedles

Cited by 19 publications

References 0 publications

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

Transdermal delivery of drugs with microneedles: Strategies and outcomes

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

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