Transdermal delivery of cyclosporin-A using electroporation

Wang, Su; Kara, M.; Krishnan, T. R.

doi:10.1016/s0168-3659(97)00117-x

Cited by 65 publications

(22 citation statements)

References 31 publications

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“…Electroporation has been used to deliver a number of small molecules, including tetracaine [282], lidocaine [283], nalbuphine [281], and cyclosporin [284]. Conjeevaram et al [285] reported no measurable permeation of fentanyl through human epidermis under passive conditions.…”

Section: Electroporationmentioning

confidence: 99%

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Morrow¹,

McCarron²,

Woolfson³

et al. 2007

TODDJ

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Abstact: Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost layer, the epidermis, which safeguards against chemical, microbial, and physical attack. The exceptional barrier properties of the skin result in it being a challenging route for the delivery of therapeutic agents. This article reviews strategies developed to enhance the skin penetration of drugs, ranging from conventional approaches, for example the use of chemical penetration enhancers to those in early-stage development, such as microscissioning.

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Section: Electroporationmentioning

confidence: 99%

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Morrow¹,

McCarron²,

Woolfson³

et al. 2007

TODDJ

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“…Several attempts have been made to increase CysA delivery to skin, which is hindered by the barrier function of the stratum corneum (SC). Penetration enhancers, physical techniques and drug delivery systems have been evaluated as strategies to increase CysA penetration in the skin (Duncan et al, 1990;Choi et al, 1995;Mizoguchi et al, 1992;Wang et al, 1997a;Wang et al, 1997b;Wang et al, 1998;Guo et al, 2000;Boinpally et al, 2004;Verma e Fahr, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…To date, few studies involve the development of methods to quantify CysA in skin models (Wang et al, 1997a;Wang et al, 1997b;Wang et al, 1998;Guo et al, 2000;Boinpally et al, 2004). The present study aimed at developing a simple method to extracted CysA from SC and epidermis (E) plus dermis (D) of porcine ear skin ([E+D]), and to assay the drug using High Pressure Liquid Chromatography (HPLC).…”

Section: Introductionmentioning

confidence: 99%

Cyclosporin A in skin samples from in vitro penetration studies may be assayed by a simple HPLC method

Lopes

Bentley

2005

Rev. Bras. Cienc. Farm.

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“…calcitonin, 9) terazosin, 10,11) alniditan, 12) fentanyl, [13][14][15] cyclosporin-A, 16) heparin, 17) metoprolol, 18,19) and LHRH. 20,21) Transport of these drugs through skin was effectively enhanced by electroporation.…”

mentioning

confidence: 99%

“…In one case, the electrodes for electroporation are set on both the stratum corneum and the dermis of excised skin, and electroporation is applied across the skin. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In the second case, the electrodes are set only on the stratum corneum and electroporation is applied on the surface of the stratum corneum. 6,22) The latter system might be more suitable for clinical applications.…”

mentioning

confidence: 99%

Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro.

Fukushima

Kishimoto

Horai

et al. 2001

Biological & Pharmaceutical Bulletin

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Transdermal enhancement effects of electroporation applied only on the stratum corneum by two electrode types, the stamp-type electrode and the frog-type electrode, were investigated in vitro using excised rat skin. Carboxyfluorescein (CF) was selected as a model compound. The excised skin was set in a Franz type diffusion cell and a square wave electric pulse was applied to the stratum corneum under various electric pulse conditions. We determined the permeability of CF to the receptor compartment under these conditions. Voltage, electric pulse length, and number of electric pulses, were varied from 10 to 1000 V, 50 m ms to 15 ms and 5 to 30 pulses, respectively. Flux rate was enhanced as the electric pulse condition strengthened. However, the maximum value was attained in the flux rate, above which no increase was observed despite strengthening of the electric pulse. Although at low electric pulses, the enhancement effect of the frog-type electrode was superior to that of the stamptype electrode, the maximum flux rates were the same. These results indicate that electroporation on the stratum corneum using the stamp-type electrode or frog-type electrode, is useful for transdermal drug delivery.

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Transdermal delivery of cyclosporin-A using electroporation

Cited by 65 publications

References 31 publications

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Cyclosporin A in skin samples from in vitro penetration studies may be assayed by a simple HPLC method

Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro.

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