Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants

Maghraby, Gamal M. El

doi:10.1016/j.ijpharm.2007.12.022

Cited by 226 publications

(176 citation statements)

References 41 publications

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“…Extrapolation of this line will intercept with the x axis at a time equal to the lag time (El Maghraby, 2008, 2010, 2012aEl Maghraby et al, 2014). The Student's t-test was used for statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

“…This ratio was selected after solubilizing the highest concentration of water on titration of a 1:1 mixture of the oil with surfactant/cosurfactant system (Alany et al, 2001). Pseudo-ternary phase diagrams were constructed at ambient temperature using water titration method (Chen et al, 2004;El Maghraby, 2008). For each phase diagram mixtures of oils and surfactant or surfactant/ cosurfactant mixtures were prepared at weight ratios of 0.5:9.5, 1:9, 1.5:8.…”

Section: Construction Of Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

“…These mixtures were titrated with water while magnetic stirring. The resultant mixtures were characterized visually after equilibration with transparent fluid systems being considered as microemulsion (El Maghraby, 2008;El Maghraby et al, 2014). Highly viscous non-fluid systems were considered as gel (El Maghraby, 2008).…”

Section: Construction Of Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

“…Excess drug was added to prepare saturated drug solutions with excess crystals being included to maintain saturation. These systems were equilibrated by continuous mixing in water bath maintained at 32 °C for 72 h before skin permeation studies (El Maghraby, 2008). Addition of excess drug did not lead to any phase change.…”

Section: Preparation Of Microemulsionsmentioning

confidence: 99%

“…This allowed investigation of skin permeation at equal thermodynamic activity in all systems and provide better chance for detecting any effect for the formulation variables on skin permeation (El Maghraby, 2008, 2010El Maghraby et al, 2014).…”

Section: Skin Permeation Studiesmentioning

confidence: 99%

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Transdermal delivery of kojic acid from microemulgel

Nagar¹,

Mahdy²,

Selem³

et al. 2016

J App Pharm Sci

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The aim of this study was to develop microemulgel for skin delivery of kojic acid. Microemulsions (ME) containing either oleic acid (OA) or caprylic/capric triglycerides as the basic oily components were developed after construction of pseudoternary phase diagrams. Tween 80 was used as surfactant for oleic acid system both in presence and absence of ethanol or propylene glycol (PG) as cosurfactants. For the caprylic/capric systems, Tween 85 was the surfactant in presence or absence of ethanol as cosurfactant. Selected ME formulations were tested for transdermal delivery of kojic acid both in fluid state and after transformation into gel. Incorporation of cosurfactants expanded the microemulsion zone. The cosurfactant free ME were more viscous. Incorporation of kojic acid in ME systems increased the transdermal flux compared to saturated aqueous solution. caprylic/capric ME were more efficient than (OA) based ME. Transformation of the tested ME systems into gel produced significant enhancement in transdermal drug delivery compared with the saturated aqueous drug solution. However, the data revealed superior efficacy for the fluid ME systems over the corresponding microemulgel. In conclusion, both (OA) and caprylic/capric ME were promising for dermal and transdermal delivery of kojic acid even after gel formation.

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Section: Discussionmentioning

confidence: 99%

Section: Construction Of Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

Section: Construction Of Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

Section: Preparation Of Microemulsionsmentioning

confidence: 99%

Section: Skin Permeation Studiesmentioning

confidence: 99%

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Transdermal delivery of kojic acid from microemulgel

Nagar¹,

Mahdy²,

Selem³

et al. 2016

J App Pharm Sci

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Eucalyptus oil nanoemulsion for enhanced skin deposition of fluticasone propionate in psoriatic plaques: A combinatorial anti‐inflammatory effect to suppress implicated cytokines

Ashraf,

El‐Sawy,

El Zaafarany

et al. 2024

Archiv der Pharmazie

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Psoriasis is a chronic inflammatory skin disease that affects patients' quality of life. This study aimed to enhance the efficacy of topical application of fluticasone propionate (FP) using a eucalyptus oil‐based nanoemulsion, an oil possessing anti‐inflammatory activity and extracted from the leaves, fruits, and buds of Eucalyptus globulus or Eucalyptus maidenii, to improve the skin deposition of FP and aid its anti‐inflammatory effect. Box‐Behnken design was employed to optimize NE formulations, which were characterized for globule size, zeta potential, polydispersity index, rheological behavior, microscopic morphology, ex vivo skin permeation/deposition, and in vivo efficacy using imiquimod‐induced psoriatic lesions. The optimized formulation depicted a droplet size of 188 ± 22.4 nm, a zeta potential of −17.63 ± 1.66 mV, and a viscosity of 204.9 mPa s. In addition to the increased FP retention in different skin layers caused by the NE and the reduced PASI score compared to the marketed cream, the levels of inflammatory cytokines IL‐1α, IL‐6, IL17a were markedly lowered, indicating the improved anti‐psoriatic curable efficacy of the optimized formulation in comparison to the FP‐marketed product.

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Topical Delivery of Lycopene using Microemulsions: Enhanced Skin Penetration and Tissue Antioxidant Activity

Lopes

VanDeWall

et al. 2010

Journal of Pharmaceutical Sciences

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Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants

Cited by 226 publications

References 41 publications

Transdermal delivery of kojic acid from microemulgel

Transdermal delivery of kojic acid from microemulgel

Eucalyptus oil nanoemulsion for enhanced skin deposition of fluticasone propionate in psoriatic plaques: A combinatorial anti‐inflammatory effect to suppress implicated cytokines

Topical Delivery of Lycopene using Microemulsions: Enhanced Skin Penetration and Tissue Antioxidant Activity

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