Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria

Sibiya, Happiness; Musabayane, C T; Mabandla, Musa V.

doi:10.1016/j.actatropica.2017.03.005

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…The triterpenoids are generally highly hydrophobic, which reduces their bioavailability and efficacy. Sibiya et al showed that once off application of an-OA patch reduces parasitemia and TNF-α plasma levels [137]. Exposure of the host to malaria activates macrophages which in turn induces production of TNF-α and then the release of other cytokines such as IL-6 which initiate inflammation.…”

Section: Maslinic Acid (Ma) and Oleanolic Acid (Oa)mentioning

confidence: 99%

Malarial Inflammation-Driven Pathophysiology and Its Attenuation by Triterpene Phytotherapeutics

Mavondo¹,

Mkhwanazi²,

Mzingwane³

et al. 2020

Parasitology and Microbiology Research

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Malaria driven pathophysiology inimically conjoined to systemic inflammation response cascade in a vicious feed-forward cycle destined to a terrible debilitation or demise of the host. The Plasmodium parasite initiates physiological changes when it is transmitted into the human host by intermediate host and vector. Sporozoites injection elicits immunological and inflammatory response suppression facilitating movement into the blood stream undetected, destined to hepatocyte. Subsequently, hepatocyte invasion culminates in intracellular growth and conversion of the parasites rapturing hepatocytes releasing merozoites into the extrahepatic circulation. Inflammatory and immunological response initiation results in overt malarial disease symptoms. Initially, inflammatory response alleviates and curtails infection. Activation of leukocytes, lymphocytes, monocytes, and phagocytes secretes inflammatory mediators, chemokines, cytokines cytoadhering molecules which accelerate infection patency. Hormonal processes influence disease tolerance without necessarily interfering with parasitemia. Current treatment is anti-parasitic. Phytotherapeutic intervention in malaria is anti-parasitic and anti-disease effects that terminate the vicious cycle and alleviating disease. The phytochemicals, in malarial experimental and clinical work, include asiatic acid, maslinic acid, oleanolic acid, and inflammatory and immunological aberrations evolving in malaria and the effects of phytochemical therapeutics in the alleviation of the disease to enable leverage of future treatment regimens through harnessing existing plants materials is explored.

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Section: Maslinic Acid (Ma) and Oleanolic Acid (Oa)mentioning

confidence: 99%

Malarial Inflammation-Driven Pathophysiology and Its Attenuation by Triterpene Phytotherapeutics

Mavondo¹,

Mkhwanazi²,

Mzingwane³

et al. 2020

Parasitology and Microbiology Research

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“…You can freely access the chapter at the Web Viewer here. structured triterpene, oleanolic acid (OA), has been reported to attenuate proinflammatory cytokines (TNF-α and IL-6) release and ameliorate anemia in murine malaria [106], properties that AA has been reported to have in other inflammatory conditions [107].…”

Section: Immune System As Mediator Of Sma Generationmentioning

confidence: 99%

“…Overall, TNF-α seem to be the main orchestrator of inflammation and that the anti-inflammatory effects of AA through inhibition of inflammatory mediators influence hypoglycaemia amelioration in malaria [30]. Indeed, the biologically active pentacyclictriterpenoid compounds oleanolic acid (OA) and maslinic acid (MA) have been shown to clear parasitic infection and ameliorate hypoglycaemia associated with malaria [106,166] (Figure 5).…”

Section: Malarial Hypoglycaemia Expression and The Oxidative Stress Pmentioning

confidence: 99%

Malarial Pathophysiology and Phytochemical Interventions: A Current Discourse on Oxidative Stress Anti-Disease Phytotherapeutics

Mavondo¹,

Mkhwanazi²,

Mavondo³

et al. 2019

Malaria

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Malarial systemic pathophysiology refers to physiological changes or abnormalities that are experienced by individuals infected with the Plasmodium parasite not be presenting in the absence of active, chronic or previous infection. The pathologies are derived, in part, from OS induced insults whose mediators are readily available in malaria. The malaria disease is equivalent to the pathophysiology as shown by the abnormal syndromic expressions ranging from ailments that affect homeostatic mechanisms and processes to tissues and organ specific damages and derangements. Phytotherapeutic remedies refer to the natural phytochemicals or plant medicinal compounds and their derivatives with known antiparasitic and antimalarial disease effects in both experimental and clinical situations. The chapter explores how Plasmodium infection generates or cause to be generated oxidative stress, how oxidative stress drives systemic disease process and how phytotherapeutics treatment (artemisinins) and administration (asiatic acid) in malaria resolves the various pathologies as a current situational analysis.

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Recent advances in biopolymer-based transdermal patches

Güngör

Kahraman

Erdal

et al. 2020

Biopolymer Membranes and Films

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Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria

Cited by 5 publications

References 48 publications

Malarial Inflammation-Driven Pathophysiology and Its Attenuation by Triterpene Phytotherapeutics

Malarial Inflammation-Driven Pathophysiology and Its Attenuation by Triterpene Phytotherapeutics

Malarial Pathophysiology and Phytochemical Interventions: A Current Discourse on Oxidative Stress Anti-Disease Phytotherapeutics

Recent advances in biopolymer-based transdermal patches

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