Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/gelatin-based microneedles for the prevention and treatment of hypertrophic scars

Hao, Ruiqi; Wang, Chun; Yang, Chunxu; Chang, Jingjing; Wang, Xiqiao; Yuan, Bo; Xu, Haiting; Zhou, Sen; Fan, Chen; Li, Zhiming

doi:10.1016/j.ejpb.2023.02.003

Cited by 10 publications

(7 citation statements)

References 37 publications

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“…[39] Besides, many other substances have also been used in the treatment of HS in MNP. For instance, tanshinone IIA, [128] asiaticoside, [47] betamethasone, [124] losartan, [126] bleomycin, [37] choloroquin, [125] interferon, [127] and tranilast. [40] The utilization of various materials to construct distinct segments of the needle body carrying different cargoes, enabling phased release at different levels, represents a promising direction for future MNP development.…”

Section: Cargo Interventionmentioning

confidence: 99%

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

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Wounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

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Section: Cargo Interventionmentioning

confidence: 99%

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

Small

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“…However, these MNs exhibit poor biocompatibility and fail to meet the demands of moist wound healing. While dissolving MNs and hydrogel MNs possessing high biophilic, high porosity, and intelligent response have emerged as the most extensively applied (Wu et al, 2021;Yi et al, 2021;Hao et al, 2023;Zeng et al, 2023). Copyright 2023, Wiley.…”

Section: Manufacture and Therapeutic Advantages Of Microneedles In Wo...mentioning

confidence: 99%

Section: Manufacture and Therapeutic Advantages Of Microneedles In Wo...mentioning

confidence: 99%

“…PA can trigger apoptosis in HSFs, however, interestingly, at 50 μM and 100 μM, PA does not exhibit significant inhibitory effects on human normal fibroblasts. Further experiments demonstrated that PA mitigates excessive deposition of native proteins by suppressing the expression of COL1A1 (Collagen I), COL3A, ACTA1 (α-smooth muscle actin), and matrix metalloproteinase-3 (MMP3) in HSFs (Hao et al, 2023) (Figure 9A).…”

Section: Phenolic Compounds: Curcumin Carvacrol and Protocatechuic Al...mentioning

confidence: 99%

mentioning

confidence: 99%

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Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang,

Li,

You

et al. 2023

Front. Bioeng. Biotechnol.

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Wound healing is a dynamic and complex restorative process, and traditional dressings reduce their therapeutic effectiveness due to the accumulation of drugs in the cuticle. As a novel drug delivery system, microneedles (MNs) can overcome the defect and deliver drugs to the deeper layers of the skin. As the core of the microneedle system, loaded drugs exert a significant influence on the therapeutic efficacy of MNs. Metallic elements and herbal compounds have been widely used in wound treatment for their ability to accelerate the healing process. Metallic elements primarily serve as antimicrobial agents and facilitate the enhancement of cell proliferation. Whereas various herbal compounds act on different targets in the inflammatory, proliferative, and remodeling phases of wound healing. The interaction between the two drugs forms nanoparticles (NPs) and metal-organic frameworks (MOFs), reducing the toxicity of the metallic elements and increasing the therapeutic effect. This article summarizes recent trends in the development of MNs made of metallic elements and herbal compounds for wound healing, describes their advantages in wound treatment, and provides a reference for the development of future MNs.

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Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Kang,

Liu,

Chen

et al. 2024

Advanced NanoBiomed Research

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Skin pathological fibrosis conditions, such as hypertrophic scars (HS) and keloids, where the scar tissue is raised and extends beyond the original wound boundary, are aesthetically unappealing and sometimes painful or itchy, significantly impacting the life quality of patients. In this review, the advances of nanobiomaterials in treating skin pathological fibrosis are summarized and discussed. The focus is on the therapeutic approaches to cellular and molecular targets of HS, highlighting the potential of nanotechnology in scar management. The biofunctional nanomaterials can modulate inflammation, regulate angiogenesis, and promote fibroblast apoptosis. The nanotechnology‐based drug delivery systems such as liposomes, ethosomes, and dendritic macromolecules can improve the solubility, stability, and efficacy of drugs, and enhance precise delivery, resulting in better outcomes in HS therapy. Integrating nanomaterials or nanostructures into hydrogels, nanofibers, and microneedles can enhance the biological functionality and maximize the therapeutic effect of nanoparticles (NPs) at the wound site. The important potential of nanotechnology‐based scar treatment should be further explored to overcome the current challenges and promote its application in clinical practice.

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Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/gelatin-based microneedles for the prevention and treatment of hypertrophic scars

Cited by 10 publications

References 37 publications

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

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