Transdermal delivery of salbutamol sulphate: Formulation and evaluation

El-Gendy, Nashwa; Sabry, Nirmeen A.; El-Attar, M; Omar, Emad; Mahmoud, Mohamed Ashraf

doi:10.1080/10837450802572383

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…The thicknesses of the drug-loaded polymeric patches were measured with the use of a screw gauge at five different points 25 . To measure the thickness, patches from each batch were placed between two glass slides of known thickness.…”

Section: Physical Characterizationmentioning

confidence: 99%

Effect of Essential Oils on Transdermal Permeation of Metoprolol Succinate

Sorathia

Patel

Soni

et al. 2021

Bulletin of Pharmaceutical Sciences. Assiut

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The objective of the present study was to prepare a matrix-type transdermal drug delivery system containing metoprolol succinate and to evaluate the effect of essential oils on transdermal permeation of drug. The solvent evaporation method was employed to fabricate transdermal patches of drug using HPMC K15M and Acrycoat L100 as polymers and polyethylene glycol 400 as a plasticizer. Prepared patches were subjected for evaluation of physical as well as physicochemical properties, moisture characteristics, and ex-vivo drug permeation studies. The results of physical characterization showed uniform casting and good appearance of patches. Satisfactory mechanical strength was revealed in the results of tensile strength and folding endurance. Ex-vivo permeation study indicated enhancing effect of essential oils on drug permeation through the skin. The maximum flux observed was 94 µg/cm2.hr achieved by formulation M3 containing lemongrass oil (20%). The results suggested that lemongrass oil was effective at higher concentration (20%) after 14 hrs of permeation while peppermint oil and eucalyptus oil were effective at low concentration (10%). Release kinetic suggested diffusion-controlled release of drug which followed the Korsmeyer-Peppas model. In conclusion, essential oils can be utilized as a safe and effective alternative for the permeation enhancement of drugs through transdermal delivery. Authors are thankful to Troikaa Pharmaceuticals Ltd., Ahmedabad for providing gift sample of Metoprolol succinate. Authors are also thankful to Shin-Etsu Chemical Co. Ltd., Japan and Corel Pharma Chem, Ahmedabad for providing Metolose (HPMC) and Acrycoat L100 as gift samples.

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Section: Physical Characterizationmentioning

confidence: 99%

Effect of Essential Oils on Transdermal Permeation of Metoprolol Succinate

Sorathia

Patel

Soni

et al. 2021

Bulletin of Pharmaceutical Sciences. Assiut

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“…Two-dimensional spherulitc assemblies of small organic molecules could potentially be applied as a transdermal technology, 35,36 where SS can permeate across the skin through passive diffusion. 37 One of the advantages of using spherulites is that they possess an enhanced mechanical strength compared to their nonspherulitic deposits, 38 which indicates that the growth of SS spherulites on the surface of different substrates employed in the fabrication of mucoadhesive transdermal or buccal patches could be used to develop drug delivery systems for the control of pulmonary diseases.…”

Section: Methodsmentioning

confidence: 99%

“…However, it is crucial to inhibit the interactions between the assembling molecules and the substrate in order to facilitate the molecule grouping from individual crystals to the spherulitic arrangement, especially at lower growing rates under mild nonequilibrium conditions. 2D spherulitc assemblies of small organic molecules could potentially be applied as a transdermal technology [35][36] , where SS can permeate across the skin through passive diffusion 37 . One of the advantages of using spherulites is that they possess an enhanced mechanical strength compared to their non-spherulitic deposits 38 which…”

Section: Mechanism Of Spherulitic Formationmentioning

confidence: 99%

Impact of Substrate Properties on the Formation of Spherulitic Films: A Case Study of Salbutamol Sulfate

Serrano

Mugheirbi

O’Connell

et al. 2016

Crystal Growth & Design

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Spherulitic assemblies have applications as carriers for drug delivery and as targeting vectors. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. Herein, the impact of different substrate types on spherulitic crystallization of salbutamol sulfate (SS) was investigated. Freshly cleaved mica, silicon (111) wafer (SiW), uncoated borosilicate glass (UG), silane coated glass (CG) and stainless steel (MS) were used as substrates. It was demonstrated that the spherulite growth can be controlled via the substrate selection. Spherulite formation was inhibited on hydrophilic substrates, such as mica, possibly due to stronger intermolecular interactions between SS and the substrate than SS-SS interactions. Contact angle measurements established that mica possessed the lowest contact angle (15.1±0.5°) and the values of this parameter increased in the order of UC˂SiW˂CG˂MS. Substrate roughness also played a key role in controlling spherulite formation. SiW, UC and CG had isotropic surfaces with low average roughness, facilitating spherulite formation. Overall, this work demonstrates that it is possible to successfully produce SS spherulites using a single step process at room temperature. Furthermore, the formation of SS spherulites can be tuned by the hydrophobicity of the substrate, an approach that could be applied to assembling spherulites of other small organic molecules. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. Herein, the impact of different substrate types on spherulitic crystallization of salbutamol sulfate (SS) was investigated. Freshly cleaved mica, silicon (111) wafer (SiW), uncoated borosilicate glass (UG), silane coated glass (CG) and stainless steel (MS) were used as substrates. It was demonstrated that the spherulite growth can be controlled via the substrate selection. Spherulite formation was inhibited on hydrophilic substrates, such as mica, possibly due to stronger intermolecular interactions between SS and the substrate than SS-SS interactions. Contact angle measurements established that mica possessed the lowest contact angle (15.1±0.5°) and the values of this parameter increased in the order of UC˂SiW˂CG˂MS. Substrate roughness also played a key role in controlling spherulite formation. SiW, UC and CG had isotropic surfaces with low average roughness, facilitating spherulite formation. Overall, this work demonstrates that it is possible to successfully produce SS spherulites using a single step process at room temperature. Furthermore, the formation of SS spherulites can be tuned by the hydrophobicity of the substrate, an approach that could be applied to assembling spherulites of other small organic molecules.

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“…The weight variation test was done by randomly selecting three patches of each formulation. The patches were weighed individually on a digital weighing balance with a sensitivity of 0.0001 g (DV215CD, Ohaus, New Jersey, USA) …”

Section: Methodsmentioning

confidence: 99%

“…Three random patches of each formulation were selected for the test. The thickness was noted from the center and edges of patch …”

Section: Methodsmentioning

confidence: 99%

Formulation Factors Affecting In Vitro and Ex Vivo Permeation of Bisoprolol Fumarate from a Matrix Transdermal Patch

Shabbir

Ali

Farooq

et al. 2015

Adv. Polym. Technol.

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The present study was done to develop and evaluate a matrix transdermal patch for bisoprolol fumarate. Different combinations of Eudragit RS 100 and HPMC E5 were used with polyethylene glycol 400 as a plasticizer on a polyvinyl alcohol backing layer by the solvent evaporation technique. The patches were evaluated for organoleptic characteristics and physicochemical parameters. Initial in vitro dissolution experiments were conducted to optimize formulation parameters prior to ex vivo skin permeation studies. Eudragit RS 100 and HPMC E5 (9:1) combination was studied for skin permeation because of the sustain release effect. The effect of control patch and permeation enhancer including Tween 80, propylene glycol, and DMSO were evaluated at 10%-40% concentration in the Franz diffusion cell using excised abdominal skin of rabbit. Different kinetic models were used to interpret the release kinetics and drug release mechanism. The patch M04-PE containing 40% Tween 80 had better sustained release effect and had closer flux to the desired flux. M04-PE followed the zero-order kinetics with super case II release drug mechanism.

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Transdermal delivery of salbutamol sulphate: Formulation and evaluation

Cited by 5 publications

References 28 publications

Effect of Essential Oils on Transdermal Permeation of Metoprolol Succinate

Effect of Essential Oils on Transdermal Permeation of Metoprolol Succinate

Impact of Substrate Properties on the Formation of Spherulitic Films: A Case Study of Salbutamol Sulfate

Formulation Factors Affecting In Vitro and Ex Vivo Permeation of Bisoprolol Fumarate from a Matrix Transdermal Patch

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