Transdermal Delivery of Salmon Calcitonin Using a Dissolving Microneedle Array: Characterization, Stability, and In vivo Pharmacodynamics

Zhang, Lu; Li, Yingying; Wei, Fang; Liu, Huan; Wang, Yushuai; Zhao, Weiman; Dong, Zhiyong; Ma, Tao; Wang, Qingqing

doi:10.1208/s12249-020-01865-z

Cited by 49 publications

(6 citation statements)

References 39 publications

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“…Another study suggested dissolving MAPs loaded with calcitonin and prepared as two formulations depending on the compounds used for the solutionsdextran and PVP and dextran, trehalose, and PVP. The performed in vivo assays resulted in significantly increased bioavailability of the peptide compared with the conventional transdermal therapeutic system (TTS) …”

Section: Noninvasive and Microinvasive Delivery Routesmentioning

confidence: 99%

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Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Stoilov,

Truong,

Gronthos

et al. 2023

ACS Appl. Bio Mater.

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Bone tissue plays a crucial role in protecting internal organs and providing structural support and locomotion of the body. Treatment of hard tissue defects and medical conditions due to physical injuries, genetic disorders, aging, metabolic syndromes, and infections is more often a complex and drawn out process. Presently, dealing with hard-tissue-based clinical problems is still mostly conducted via surgical interventions. However, advances in nanotechnology over the last decades have led to shifting trends in clinical practice toward noninvasive and microinvasive methods. In this review article, recent advances in the development of nanoscale platforms for bone tissue engineering have been reviewed and critically discussed to provide a comprehensive understanding of the advantages and disadvantages of noninvasive and microinvasive methods for treating medical conditions related to hard tissue regeneration and repair.

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Section: Noninvasive and Microinvasive Delivery Routesmentioning

confidence: 99%

“…The performed in vivo assays resulted in significantly increased bioavailability of the peptide compared with the conventional transdermal therapeutic system (TTS). 169 2.8. Side-by-Side Comparison.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Stoilov,

Truong,

Gronthos

et al. 2023

ACS Appl. Bio Mater.

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“…Based on this design, studies have used two dissolving microneedle arrays (DMNAs) to deliver salmon calcitonin, avoiding sharp biological hazards. Compared with the traditional transdermal gel patch, DMNA can significantly improve the therapeutic effect of sCT [ 197 ], providing a feasible scheme for the treatment of bone diseases in the future. In addition, a method of combining conductive MN and ITP to achieve local anesthesia of teeth was proposed.…”

Section: Adjuvant Therapymentioning

confidence: 99%

Bone Tissue Engineering in the Treatment of Bone Defects

et al. 2022

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Bones play an important role in maintaining exercise and protecting organs. Bone defect, as a common orthopedic disease in clinics, can cause tremendous damage with long treatment cycles. Therefore, the treatment of bone defect remains as one of the main challenges in clinical practice. Today, with increased incidence of bone disease in the aging population, demand for bone repair material is high. At present, the method of clinical treatment for bone defects including non-invasive therapy and invasive therapy. Surgical treatment is the most effective way to treat bone defects, such as using bone grafts, Masquelet technique, Ilizarov technique etc. In recent years, the rapid development of tissue engineering technology provides a new treatment strategy for bone repair. This review paper introduces the current situation and challenges of clinical treatment of bone defect repair in detail. The advantages and disadvantages of bone tissue engineering scaffolds are comprehensively discussed from the aspect of material, preparation technology, and function of bone tissue engineering scaffolds. This paper also summarizes the 3D printing technology based on computer technology, aiming at designing personalized artificial scaffolds that can accurately fit bone defects.

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“…However, in addition to the drug dose being limited by the coating thickness, such metal MNs were prone to breakage and cause skin inflammation. Zhang et al 24 developed two sCT-loaded dissolving microneedle patches based on poly-(vinylpyrrolidone) (PVP). The mechanical properties and drug distribution of the patches met the requirements of transdermal administration, which can significantly increase the relative bioavailability of sCT to about 70%.…”

Section: Introductionmentioning

confidence: 99%

Composite Separable Microneedles for Transdermal Delivery and Controlled Release of Salmon Calcitonin for Osteoporosis Therapy

et al. 2022

ACS Appl. Mater. Interfaces

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A composite separable microneedles (MNs) system consisting of silk fibroin (SF) needle tips and hyaluronic acid (HA) base is developed for transdermal delivery of salmon calcitonin (sCT) for therapy of osteoporosis. Poly(ethylene glycol) (PEG) is used to modulate the conformation structure of SF to achieve controllable sustained release of sCT. The prepared MNs can effectively penetrate the skin stratum corneum. After application to the skin, the HA base is dissolved within 2 min, allowing these SF drug depots to be implanted into the skin for controllable sustained release of sCT. The release kinetics of sCT can be controlled by regulating the conformation of SF with PEG and the interaction between sCT peptide and SF proteins. Compared with traditional needle injection, delivery of sCT using optimized HA-PEG/SF MNs shows better trabecular bone repair for ovariectomized-induced osteoporosis in mice. The proposed MNs system provides a new noninjection strategy for therapy of osteoporosis.

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Transdermal Delivery of Salmon Calcitonin Using a Dissolving Microneedle Array: Characterization, Stability, and In vivo Pharmacodynamics

Cited by 49 publications

References 39 publications

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Bone Tissue Engineering in the Treatment of Bone Defects

Composite Separable Microneedles for Transdermal Delivery and Controlled Release of Salmon Calcitonin for Osteoporosis Therapy

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