Transdermal drug delivery <i>via</i> microneedles for musculoskeletal systems

Zheng, Haibin; Xie, X. X.; Ling, Hua; You, Xintong; Liang, Siyu; Lin, Rurong; Qiu, Renjie; Hou, Honghao

doi:10.1039/d3tb01441j

Cited by 5 publications

(4 citation statements)

References 214 publications

(240 reference statements)

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“…Most patients saw decreased edoema within a month and 80% felt better after the first month of treatment. Ayurvedic medication did not cause any toxicity in the liver, kidneys, or anywhere else in the body (Zheng et al, 2023).…”

Section: Discussionmentioning

confidence: 84%

Efficacy and Safety of Muscle Rub Ointment in The Management of Arthritis and Certain Musculoskeletal Disorders

Singh,

Sharma

2023

IJERR

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Traditional Indian medicine has long used Muscle Rub Ointment to treat rheumatoid arthritis (RA), but its safety and effectiveness have not been well studied. To bridge this gap, an extensive investigation was carried out to evaluate the efficacy and safety of a specially designed Muscle Rub Ointment for individuals with RA. Over a 7-year period, 290 RA patients received customized care from Ayurvedic doctors in accordance with established practices. The American Rheumatism Association criteria were used for monitoring every six weeks, and treatment regimens varied from one to six months. Based on statistical analysis (repeated measures t-test), 33 discharged patients' first-year data were the subject of the study. There were notable improvements even among the most severely disabled patients in a number of indicators, such as functional class, rheumatoid factor, grip strength, walking time, swollen joints, painful joints, joint count, and erythrocyte sedimentation rate. Despite the fact that some patients did not get regular follow-up, the data that was available indicated persistent gains after discharge, especially in grip strength. The results of this study highlight the potential benefits of using ancient Ayurvedic medicine to treat RA and highlight the need for further emphasizing the need for further controlled investigations into its efficacy.

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Section: Discussionmentioning

confidence: 84%

Efficacy and Safety of Muscle Rub Ointment in The Management of Arthritis and Certain Musculoskeletal Disorders

Singh,

Sharma

2023

IJERR

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“…According to the metanalysis elaborated by Skinner et al [88], intramuscular testosterone replacement therapy offers a 3-5 times increase in muscle mass and strength than transdermally administered testosterone. One more emerging delivery possibility is using microneedle patches loaded with micronsized needle arrays for non-invasively injecting therapeutic agents to treat musculoskeletal disorders [89]. Nonetheless, further studies dedicated to sarcopenia need to be performed for clarifying the exact outcomes of microneedle patch administration in this disease.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

Najm,

Niculescu,

Grumezescu

et al. 2024

IJMS

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Sarcopenia is a prevalent degenerative skeletal muscle condition in the elderly population, posing a tremendous burden on diseased individuals and healthcare systems worldwide. Conventionally, sarcopenia is currently managed through nutritional interventions, physical therapy, and lifestyle modification, with no pharmaceutical agents being approved for specific use in this disease. As the pathogenesis of sarcopenia is still poorly understood and there is no treatment recognized as universally effective, recent research efforts have been directed at better comprehending this illness and diversifying treatment strategies. In this respect, this paper overviews the new advances in sarcopenia treatment in correlation with its underlying mechanisms. Specifically, this review creates an updated framework for sarcopenia, describing its etiology, pathogenesis, risk factors, and conventional treatments, further discussing emerging therapeutic approaches like new drug formulations, drug delivery systems, stem cell therapies, and tissue-engineered scaffolds in more detail.

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“…4 On the other hand, microneedle (MN) patches, which consists of an array of micrometer-sized needles placed on a base support, could help to overcome this problem as it provides fast and painless transdermal drug delivery. 5–7 Moreover, loading 1 week – 12 days requirement of iron in a slow-release biodegradable MN patch would address the issues of bioavailability as well as unpleasant side-effects, at the same time eliminating the need for daily oral supplementary intake, and thus reducing non-compliance risks. There are several iron-containing topical patches available on the market ( e.g.…”

Section: Introductionmentioning

confidence: 99%

A microneedle transdermal patch loaded with iron(ii) nanoparticles for non-invasive sustained delivery to combat anemia

Surekha,

Misra,

Thippaiah

et al. 2024

Mater. Adv.

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Transdermal drug delivery via microneedles for musculoskeletal systems

Abstract: As the population ages and lifestyles change, the prevalence of musculoskeletal (MSK) disorders is gradually increasing with each passing year, posing a serious threat to the health and quality of...

Cited by 5 publications

References 214 publications

Efficacy and Safety of Muscle Rub Ointment in The Management of Arthritis and Certain Musculoskeletal Disorders

Efficacy and Safety of Muscle Rub Ointment in The Management of Arthritis and Certain Musculoskeletal Disorders

Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

A microneedle transdermal patch loaded with iron(ii) nanoparticles for non-invasive sustained delivery to combat anemia

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