Transdermal Drug Delivery Systems: A Mini Review.

Patel, Rakesh P.; Patel, Ankita; Prajapati, Bijal; Shinde, Gajanan; Dharamsi, Abhay

doi:10.21474/ijar01/7109

Cited by 12 publications

(3 citation statements)

References 13 publications

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“…The value of weight uniformity [15] : Test the patch after four hours at 60°C. Weigh each patch piece after it has been cut up.…”

Section: Pharmacokinetics Of Excipientsmentioning

confidence: 99%

A Review on Transdermal Drug Deivery System

Verma¹

2022

YMER

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Alginate and chitosan polymers are widely used in the preparation of drug release. These two polymers can be used together or separately to form modified drug-loaded release beads. A method of ionotropic gelation and subtle modification in various ways is used to fix these beads of different characteristics. Bead characteristics such as morphology, buoyancy, inflammatory environment, drug efficacy, marketing, and liberal behavior are important and the therapeutic use of various bead modifications can be great for underwater soluble drugs, half-life biological Health, requires direct organ guidance, and has natural protein. The need for longer and better control over drug administration has increased the need for stitched polymers. Hydrocolloids such as alginate can play an important role in the production of a controlled by-product. At low pH the flow of, alginic acid leads to the formation of a high-viscosity ‘‘acid gel.’’ Alginate is also easily applied to the gel in the presence of a divalent cation like calcium ion. This review discusses the current use the future opportunities for alginate as a tool in drug development. Keywords: Alginate, chitosan, Controlled Release, Drug Delivery, ionotropic gelation, beads.

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“…The value of weight uniformity [15] : Test the patch after four hours at 60°C. Weigh each patch piece after it has been cut up.…”

Section: Pharmacokinetics Of Excipientsmentioning

confidence: 99%

A Review on Transdermal Drug Deivery System

Verma¹

2022

YMER

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“…This is referred to as transdermal administration, and the drug delivery methods are referred to as "transdermal therapeutic systems" or more commonly as "transdermal patches". A transdermal patch, also known as a skin patch, is an adhesive patch that is applied to the skin and contains medication that is intended to be absorbed into the bloodstream through the skin [7,8]. Transdermal therapy systems are described as discrete, self-contained dosage forms that, when applied to healthy skin, transport drugs to the bloodstream at a controlled rate through the skin.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Transdermal Patches of Clotrimazole

Jagadeesh,

Kiran,

Naveena B

et al. 2023

Fut J. Pharm & H. Sci

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The aim of the present research work was to formulate Transdermal patches of Clotrimazole and to enhance effectiveness and to avoid side effects of the drug. Transdermal patch of clotrimazole was prepared with EC and HPMC in different ratios in order to improve the drug diffusion. Clotrimazole has formulated Transdermal patches were prepared by solvent evaporation technique. Drug and polymers has been characterized by FT-IR. The FTIR spectra of formulation shows that no interaction between drug and excipient. The evaluation of Transdermal patches of Clotrimazole were performed mainly for their Physical parameters such as Weight variation, Thickness, Folding endurance test And also for their Drug content and In-vitro Drug diffusion studies. The patch prepared by solvent evaporation technique passes the prepared patch were found to be non irritant, weight variation was found in the range of 39±5.81 to 48±2.90mg, thickness in the range of 0.08±0.09 to 0.04±0.08 mm, Folding endurance of patches was found to be in the range of 98 ±0.57 to 128±0.59, The tensile strength of the patches was ranging from 1.95±1.2to 3.98±1.9, The percentage elongation ranges from 10.6 to 18.6, drug content uniformity was in between 78.25 to 89.76 %. The in-vitro drug diffusion profiles of the formulations in pH 7.4 show differences depending on their composition. A Tran’s dermal patches of all the preparations were observed by the diffusion test. It was also observed that F6 showed highest drug release.

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“…Since no loss by hepatic degradation occurs, the drug can be administered in lower doses, decreasing the eventual side effects of the drug. Moreover, it provides longer periods of drug release, eliminating plasma fluctuations [10,11]. In addition, in transdermal therapies, patients' compliance is more because it is painless, convenient, therapeutically more effective, welltolerated, esthetical, easy-to-handle, and cost-effective.…”

Section: Introductionmentioning

confidence: 99%

Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats.

MACIT,

DUMAN,

MACIT

2023

jrp

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Recently, transdermal drug delivery has become popular due to their numerous advantages. They offer non-invasive application and eliminate the first-pass metabolism. The skin membrane is sensitive to heat and vibration that these applications enhance the skin permeability resulting in increased bioavailability. This study aims to determine the effect of steam bath (STB), vibration (VIB) and thermal ablation (THAB) on systemic absorption of tramadol HCl and compare all applications with each other. After preparing of tramadol HCl patches, in vitro release tests followed by in vivo animal experiments were conducted. The patches were applied to 32 Wistar albino rats divided into four groups: No potential trigger effect (NPTE), STB, VIB, and THAB. STB, VIB and THAB were applied by purchased devices. One hour later, the patches were removed and plasma concentration of tramadol HCl was measured by UV-Vis spectrophotometry at 271 nm. When compared to the control group, calculated plasma tramadol HCl µg/mL concentration increased significantly in STB, VIB and THAB (p<0.001). Finally, as trigger effects, steam bath, vibration and thermal ablation (42°C) dramatically increased the absorption amount of tramadol HCl (42.1%, 37.2 % and 43.8 %, respectively). The percentage release of tramadol HCl increased significantly in investigation groups when compared to NPTE (p<0.001). In conclusion, controlled heat and vibration applications are effective in the enhancement of transdermal drug absorption.

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Transdermal Drug Delivery Systems: A Mini Review.

Cited by 12 publications

References 13 publications

A Review on Transdermal Drug Deivery System

A Review on Transdermal Drug Deivery System

Formulation and Evaluation of Transdermal Patches of Clotrimazole

Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats.

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