Transdermal Drug Delivery Systems: Different Generations and Dermatokinetic Assessment of Drug Concentration in Skin

Kushwaha, Rahul; Palei, Narahari N.

doi:10.1007/s40290-024-00537-8

Pharm Med

2024

DOI: 10.1007/s40290-024-00537-8

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Transdermal Drug Delivery Systems: Different Generations and Dermatokinetic Assessment of Drug Concentration in Skin

Rahul Kushwaha,

Narahari N. Palei

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2024

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Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Kim,

Jung,

Kim

2024

Antioxidants

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Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). In these diseases, oxidative stress can disrupt the blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases.

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Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Kim,

Jung,

Kim

2024

Antioxidants

View full text Add to dashboard Cite

show abstract

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Transdermal Drug Delivery Systems: Different Generations and Dermatokinetic Assessment of Drug Concentration in Skin

Cited by 1 publication

References 118 publications

Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

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