Transdermal formulations and strategies for the treatment of osteoporosis

Martínez, Angélica Villanueva–; Merino, Virginia; Ganem-Rondero, Adriana

doi:10.1016/j.jddst.2022.103111

Cited by 6 publications

(5 citation statements)

References 100 publications

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“…From Table 1, the lipophilicity of drugs may be classified as CFZ >>> RIF >> INH >> PZY. These physicochemical properties were considered in order to obtain an exceptional dermal drug delivery capacity for the SDEDDSs, as the optimal lipophilicity of drugs destined for dermal drug delivery is established at a Log P value of 1-3 and a molecular weight <500 Da [32][33][34]. None of the selected drugs has a Log P value that falls within the prescribed range for desirable dermal drug delivery.…”

Section: Methods For Drug and Excipient Selectionmentioning

confidence: 99%

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

van Staden,

Haynes,

Viljoen

2023

Pharmaceuticals

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Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux as mediated by P-glycoprotein, enhanced lymphatic drug uptake, improved control over plasma concentration profiles of drugs, enhanced stability, and drug loading efficiency. Interest in dermal spontaneous emulsions has increased, given that systems have been reported to deliver drugs across mucus membranes, as well as the outermost layer of the skin into the underlying layers. The background and development of a double spontaneous emulsion incorporating four anti-tubercular drugs, clofazimine (CFZ), isoniazid (INH), pyrazinamide (PZY), and rifampicin (RIF), are described here. Our methods involved examination of oil miscibility, the construction of pseudoternary phase diagrams, the determination of self-emulsification performance and the emulsion stability index of primary emulsions (PEs), solubility, and isothermal micro calorimetry compatibility and examination of emulsions via microscopy. Overall, the potential of self-double-emulsifying drug delivery systems (SDEDDSs) as a dermal drug delivery vehicle is now demonstrated. The key to success here is the conduct of preformulation studies to enable the development of dermal SDEDDSs. To our knowledge, this work represents the first successful example of the production of SDEDDSs capable of incorporating four individual drugs.

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Section: Methods For Drug and Excipient Selectionmentioning

confidence: 99%

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

van Staden,

Haynes,

Viljoen

2023

Pharmaceuticals

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“…Second-generation TDDSs have laid the foundation for maximizing drug delivery efficiency, but limitations still exist. How to balance maximizing the passage through the SC and protecting deep tissues from damage was a problem faced and urgently needed to be solved with second-generation TDDSs, which led to the emergence of third-generation TDDSs 56 .…”

Section: Transdermal Drug Delivery Systemsmentioning

confidence: 99%

“…The special structure of the SC makes it highly demanding for the properties of the drug, including moderate molecular weight, appropriate oil-water partition coefficient (log P ) value, suitable melting point, solubility, etc. 56 . Therefore, nonconforming drugs need to be modified to allow them to better penetrate the skin.…”

Section: Enhancement Strategies For Tddssmentioning

confidence: 99%

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Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis

Zhao

Cao

et al. 2023

Acta Pharmaceutica Sinica B

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“…In addition, for bisphosphonates, engineering a suitable carrier can reduce gastrointestinal irritation beyond bioavailability enhancement [ 73 ]. Villanueva-Martínez et al [ 74 ] developed two nano-systems (microemulsions and nanosuspensions) for transdermal delivery of sodium alendronate. In vivo, tests showed that neither microemulsions nor nanosuspensions exhibited skin irritation.…”

Section: Engineering Of Anti-op Drugs Deliverymentioning

confidence: 99%

Drug Delivery and Therapy Strategies for Osteoporosis Intervention

Ma,

Zeng,

Yang

et al. 2023

Molecules

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With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or formulation strategy can achieve targeted drug delivery to the bone, diminish side effects, improve bioavailability, and prolong the in vivo residence time, thus effectively curing osteoporosis. This review expounds on the pathogenesis of OP and the clinical medicaments used for OP intervention, proposes the design approach for anti-OP drug delivery, emphatically discusses emerging novel anti-OP drug delivery systems, and enumerates anti-OP preparations under clinical investigation. Our findings may contribute to engineering anti-OP drug delivery and OP-targeting therapy.

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Transdermal formulations and strategies for the treatment of osteoporosis

Cited by 6 publications

References 100 publications

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis

Drug Delivery and Therapy Strategies for Osteoporosis Intervention

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