Transdermal iontophoretic application of l-NAME is available in sweating research induced by heat stress in young healthy adults

Okamoto, Yumi; Otsuka, Junto; Aoki, Mao; Amano, Tatsuro

doi:10.1016/j.niox.2023.08.001

Nitric Oxide

2023

DOI: 10.1016/j.niox.2023.08.001

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Transdermal iontophoretic application of l-NAME is available in sweating research induced by heat stress in young healthy adults

Yumi Okamoto,

Junto Otsuka,

Mao Aoki

et al.

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2024

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Cited by 1 publication

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Partial involvement of nitric oxide synthase in increased pilocarpine-induced sweating in exercise-trained men

Okamoto,

Otsuka,

Amano

2024

Appl. Physiol. Nutr. Metab.

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The physiological mechanisms involved in augmented cholinergic agonist-induced sweating in exercise-trained individuals remain unclear. This study hypothesizes that nitric oxide synthase (NOS) contributes to augmented pilocarpine-induced sweating in habitually exercise-trained individuals. Endurance-trained and untrained men (n=15 each) iontophoretically received 1% L-NAME, a NOS inhibitor, and saline (control) in the forearm and then administered 0.001% and 1% pilocarpine to evaluate sweat rate. L-NAME administration attenuated pilocarpine-induced sweating by 10% in the exercise-trained (P = 0.004) but not in untrained (P = 0.764) groups independent of pilocarpine concentrations. Results indicate that NOS partially contributes to increased cholinergic sweating in exercise-trained men.

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Partial involvement of nitric oxide synthase in increased pilocarpine-induced sweating in exercise-trained men

Okamoto,

Otsuka,

Amano

2024

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

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Transdermal iontophoretic application of l-NAME is available in sweating research induced by heat stress in young healthy adults

Cited by 1 publication

References 47 publications

Partial involvement of nitric oxide synthase in increased pilocarpine-induced sweating in exercise-trained men

Partial involvement of nitric oxide synthase in increased pilocarpine-induced sweating in exercise-trained men

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