Transdermal microneedles for drug delivery applications

Teo, Ai Ling; Shearwood, C.; Ng, Kian Chye; Lu, Jia; Moochhala, Shabbir

doi:10.1016/j.mseb.2006.02.008

Cited by 97 publications

(66 citation statements)

References 12 publications

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“…[8,9] This paper has focused on modelling insulin delivery from a microneedle system. Insulin delivery is needed for various medical reasons such as lowering the blood glucose levels in the treatment of diabetes, [10] reducing the infarct size and hence improving 60 the diagnosis of the patient once the stroke occurred, [11] etc.…”

Section: Introduction 35mentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood

Al-Qallaf

Das

Davidson

2009

Asia-Pacific J Chem Eng

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Drug administration through transdermal delivery is restricted by the top layer of skin, the stratum corneum. One possible solution to overcome the barrier function of the stratum corneum is to employ microneedle arrays. However, detailed theoretical models relating drug‐coated microneedles and their geometry to the drug concentration in the blood are limited. This article aims to address this issue by examining the blood concentration profiles for a model drug, insulin, that has been administered via coated microneedles. A mathematical model is introduced and applied to predict theoretical blood concentrations. Furthermore, the insulin concentration in blood is calculated for a range of different microneedle shapes and dimensions to identify the most effective geometry. The results indicate that the optimum microneedle geometry in terms of maximizing insulin concentration was a rocket‐shaped needle with a constant tip angle of 90°. Also, it has been found that the number of microneedles in an array is the most significant factor in determining maximum insulin concentration in the blood (Cb, max). Penetration depth of the microneedle, centre‐to‐centre spacing and microneedle thickness had a less significant effect on the maximum insulin concentration in the blood. It is envisaged that the current study will help in designing microneedles of optimum size and shape for transdermal drug delivery. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.

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Section: Introduction 35mentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood

Al-Qallaf

Das

Davidson

2009

Asia-Pacific J Chem Eng

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“…Many relevant factors have been considered to formulate an optimized microneedle arrays, including the mask shape of the microneedle (Wilke and Morrissey, 2007), location of the microneedle hole (Khumpuang et 100 al., 2007), the microneedle tip radius (Teo et al, 2006), etc. However, most of these studies made their decision based on different criteria such as microneedle insertion, but not skin permeability, although skin permeability has been considered as a key factor that determines the efficiency of transdermal drug delivery process (Wilke et al, 2006).…”

mentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

144

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can potentially allow the transdermal delivery of many medicaments including large macromolecules that typically cannot diffuse through the skin. This paper addresses the use of microneedles coated with a drug solution film. In particular, we identify how the geometries of various microneedles affect the drug permeability in skin. Effective skin permeability is calculated for a range of microneedle shapes and dimensions in order to identify the most 20 efficient geometry. To calculate effective permeability (P eff ), the effective skin thickness (H eff ) is calculated. These are then plotted for insulin as a model drug to see how various microneedle parameters affect the profiles of both H eff and P eff . It is found that the depth of penetration from the microneedle array is the most important factor in determining P eff , followed by the microneedle spacings. Other parameters such as microneedle diameter and 25 coating depth are less significant.

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“…The methods that have been adopted for microneedle fabrication include wet etching, deep reactive ion etching (DRIE) (Teo et al, 2005), microinjection moulding (Sammoura et al, 2007), isotropic etching, isotropic etching in combination with deep etching and wet etching respectively, dry etching, isotropic and anisotropic, photolithography, thin film deposition (Moon & Lee, 2003), laser cutting (Martanto et al, 2004), and inclined LIGA process (Perennes et al, 2006). Studies have shown that factors such as microneedle geometry, coating depth on solid microneedle and skin thickness affect the drug delivery efficiency using microneedles (Al-Qallaf et al, 2009a;2009b).…”

Section: Microneedles Manufacturingmentioning

confidence: 99%