Transdermal microneedles for the programmable burst release of multiple vaccine payloads

Tran, Khanh T. M.; Gavitt, Tyler D.; Farrell, Nicholas; Curry, Eli; Mara, Arlind B.; Patel, Avi; Brown, Lindsey J.; Kilpatrick, Shawn; Piotrowska, Roxana; Mishra, Neha; Szczepanek, Steven M.; Nguyen, Thanh D.

doi:10.1038/s41551-020-00650-4

Cited by 156 publications

(130 citation statements)

References 37 publications

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“…[1,2] Microneedles (MNs) is a promising medical technique with the capability of painless transdermal drug delivery via a minimally invasive method, which is widely employed in vaccinations, cancer therapy, dermatological treatments, cosmetic, and so on. [3][4][5][6][7][8] Especially, MNs loaded with active drugs have also been exploited for promoting wound healing and obtained remarkable therapeutic effects benefiting from the dramatically increased contact area between the MNs patch and the wound. [9][10][11] However, the needle-body of the MNs is easy to form tiny pinholes at the wound sites, especially for some MNs fabricated by nonbiodegradable materials, such as stainless steel et al These voids are likely to cause secondary physical injury and microbial infections in the wounds.…”

Section: Introductionmentioning

confidence: 99%

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Yao

Chi

Wang

et al. 2021

Adv Healthcare Materials

171

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An infected skin wound caused by external injury remains a serious challenge in clinical practice. Wound dressings with the properties of antibacterial activity and potent regeneration capacity are highly desirable for wound healing. In this paper, a degradable, ductile, and wound-friendly Zn-MOF encapsulated methacrylated hyaluronic acid (MeHA) microneedles (MNs) array is fabricated through the molding method for promoting wound healing. Due to the damage capability against the bacteria capsule and oxidative stress of the zinc ion released from the Zn-MOF, such MNs array presents excellent antibacterial activity, as well as considerable biocompatibility. Besides, the degradable MNs array composed of photo-crosslinked MeHA possesses the superior capabilities to continuously and steadily release the loaded active ingredients and avoid secondary damage to the wound. Moreover, the low molecular weight hyaluronic acid (HA) generated by hydrolysis of MeHA is also conducive to tissue regeneration. Benefiting from these features, it has been demonstrated that the Zn-MOF encapsulated degradable MNs array can dramatically accelerate epithelial regeneration and neovascularization. These results indicate that the combination of MOFs and degradable MNs array is of great value for promoting wound healing.

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Section: Introductionmentioning

confidence: 99%

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Yao

Chi

Wang

et al. 2021

Adv Healthcare Materials

171

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“…Another advantage of PLGA for implantable applications is the versatility in its fabrication processes-such as solvent casting, compress modelling, and extrusion-that ease the integration of microelectronics onto a soft substrate [17,24]. These features make PLGA a fascinating material for not only the host substrate for biodegradable electronics but also for constructing components for drug delivery and cell growth scaffold [25] (Figure 1c). Along with PLGA, polymers such as silk and polyvinyl alcohol as well as natural wax have also proven their high feasibility to host transient implanted electronics [26,27].…”

Section: Materials For Biodegradable Implanted Devicesmentioning

confidence: 99%

Implanted Flexible Electronics: Set Device Lifetime with Smart Nanomaterials

Phan

2021

Micromachines

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Flexible electronics is one of the most attractive and anticipated markets in the internet-of-things era, covering a broad range of practical and industrial applications from displays and energy harvesting to health care devices. The mechanical flexibility, combined with high performance electronics, and integrated on a soft substrate offer unprecedented functionality for biomedical applications. This paper presents a brief snapshot on the materials of choice for niche flexible bio-implanted devices that address the requirements for both biodegradable and long-term operational streams. The paper also discusses potential future research directions in this rapidly growing field.

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“…Owing to the large population of active antigen-presenting cells in the epidermis and dermis together, the microneedle approach could potentially reduce the dose of vaccine thereby might reduce the overall vaccination cost. The dissolvable microneedle matrix encapsulated vaccine candidates are also reported to be stable for long period without the stringent requirement of cold chain storage [24,25]. A recently published data on the investigation of microneedles for delivering SARS-CoV-2 antigen for COVID-19 vaccine is reported by Kim et al [26].…”

Section: Microneedle: Minimally Invasive Techniquementioning

confidence: 99%

Mucosal and transdermal vaccine delivery strategies against COVID-19

Kumar

2021

Drug Deliv. and Transl. Res.

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Graphical abstract The years 2020 and 2021 have witnessed a COVID-19 pandemic caused by the SARS-CoV-2 virus. However, these years have also witnessed certain remarkable scientific achievements. Researchers across the globe have been trying extremely hard and accomplished in bringing vaccines a great variety of COVID-19 vaccines. Though the route of administration for the majority of these vaccines has been the intramuscular route (invasive), some laboratories are developing formulations intended for transmucosal and transcutaneous (non-invasive) administration, which are in the early phases of pre-clinical and clinical development. This short report discusses these unconventional formulations against COVID-19, in brief, to stress the importance of research in the field of drug delivery.

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Transdermal microneedles for the programmable burst release of multiple vaccine payloads

Cited by 156 publications

References 37 publications

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Implanted Flexible Electronics: Set Device Lifetime with Smart Nanomaterials

Mucosal and transdermal vaccine delivery strategies against COVID-19

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