Transdermal oestradiol replacement therapy enhances platelet constitutive nitric oxide synthase activity in postmenopausal women with type 2 diabetes mellitus

Martina, V.; Bruno, Giovanni; Origlia, C.; Gaia, Daniela; Trucco, Fulvia; Pescarmona, Gianpiero

doi:10.1046/j.1365-2265.2002.01609.x

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…observed a significant decrease in citrulline in transwomen and an increase in transmen, following CSH. The sex steroid dependency of these AA has also been demonstrated in samples of postmenopausal women receiving estrogen replacement therapy resulting in an increase in the citrulline/arginine ratio3738. Arginine and citrulline are involved in various metabolic cycles, such as the urea cycle, polyamine metabolism and nitric oxide (NO) synthesis32.…”

Section: Discussionmentioning

confidence: 99%

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

Auer

Cecil

Roepke

et al. 2016

Sci Rep

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Metabolomic analyses in epidemiological studies have demonstrated a strong sexual dimorphism for most metabolites. Cross-sex hormone treatment (CSH) in transgender individuals enables the study of metabolites in a cross-gender setting. Targeted metabolomic profiling of serum of fasting transmen and transwomen at baseline and following 12 months of CSH (N = 20/group) was performed. Changes in 186 serum metabolites and metabolite ratios were determined by targeted metabolomics analysis based on ESI-LC-MS/MS. RandomForest (RF) analysis was applied to detect metabolites of highest interest for grouping of transwomen and transmen before and after initiation of CSH. Principal component analysis (PCA) was performed to check whether group differentiation was achievable according to these variables and to see if changes in metabolite levels could be explained by a priori gender differences. PCA predicted grouping of individuals-determined by the citrulline/arginine-ratio and the amino acids lysine, alanine and asymmetric dimethylarginine - in addition to the expected grouping due to changes in sex steroids and body composition. The fact that most of the investigated metabolites did, however, not change, indicates that the majority of sex dependent differences in metabolites reported in the literature before may primarily not be attributable to sex hormones but to other gender-differences.

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Section: Discussionmentioning

confidence: 99%

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

Auer

Cecil

Roepke

et al. 2016

Sci Rep

View full text Add to dashboard Cite

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Platelet cGMP inversely correlates with age in healthy subjects

Origlia

Pescarmona

Capizzi

et al. 2004

J Endocrinol Invest

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Biochemical modifications associated with the increase in platelet activity with age are not well defined. Furthermore it is well known that the nitric oxide/cyclic 3', 5'-guanosine monophosphate (cGMP) pathway regulates platelet aggregation. The aim of the present study was to examine the relationship between platelet content of cGMP and age. 120 normal subjects, evaluating the cGMP platelet concentration, 17betaE2, IGF-I, dehydroepiandrosterone sulphate (DHEAS), insulin, plasma glucose, lipid pattern, homocysteine and PAI-I antigen, were studied. The multivariate analysis in a model with cGMP as dependent variable and with age, LDL, apolipoprotein B (ApoB), DHEAS, E2 and insulin-like growth factor (IGF)-I as independent variables shows a negative correlation between cGMP and age (p<0.01, beta=-0.388). In conclusion our data suggest that the reduced efficiency of the system constitutive nitric oxide synthase (cNOS)/guanylate cyclase represents at least one of the reasons of the increased platelet aggregability with age.

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Body Mass Index and Insulin Resistance

2004

Obstetrics &Amp; Gynecology

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Transdermal oestradiol replacement therapy enhances platelet constitutive nitric oxide synthase activity in postmenopausal women with type 2 diabetes mellitus

Abstract: Sequential opposed transdermal oestrogen replacement therapy was able to increase platelet cNOS activity in postmenopausal women with type 2 diabetes mellitus, suggesting that its use might be positive in preventing cardiovascular pathologies.

Cited by 4 publications

References 41 publications

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study

Platelet cGMP inversely correlates with age in healthy subjects

Body Mass Index and Insulin Resistance

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