Transdermal permeation of inorganic cerium salts in intact human skin

Magnano, Greta Camilla; Marussi, Giovanna; Filon, Francesca Larese; Crosera, Matteo; Bovenzi, Massimo; Adami, Gianpiero

doi:10.1016/j.tiv.2022.105381

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…On the day of the experiment, skin samples were thawed in a physiological solution at room temperature and the skin samples were cut into 4 cm 2 square sections. Skin integrity was checked by measuring the Trans Epidermal Water Loss (TEWL) (Delfin Vapometer, Delfin Technologies, Sweden), which was used in our previous work (Magnano et al, 2022a): the average TEWL values of the skin samples were found to be below 10 g m − 2 ⋅h − 1 (Guth et al, 2015).…”

Section: Human Skin Membranesmentioning

confidence: 99%

Evaluating the Role of Protective Creams on the Cutaneous Penetration of Ni Nanoparticles

Magnano¹,

Carton²,

Boccafoschi³

et al. 2023

Preprint

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Section: Human Skin Membranesmentioning

confidence: 99%

Evaluating the Role of Protective Creams on the Cutaneous Penetration of Ni Nanoparticles

Magnano¹,

Carton²,

Boccafoschi³

et al. 2023

Preprint

View full text Add to dashboard Cite

“…On the day of the experiment, skin samples were thawed in a physiological solution at room temperature, and the skin samples were cut into 4 cm 2 square sections. Skin integrity was checked by measuring the trans epidermal water loss (TEWL) (Delfin Vapometer, Delfin Technologies, Sweden), which was used in our previous work [43]: the average TEWL values of the skin samples were found to be below 10 g m −2 h −1 [44].…”

Section: Human Skin Membranesmentioning

confidence: 99%

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Magnano

Marussi

Crosera

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveBarrier creams (BCs) are marketed as locally‐applied medical devices or cosmetic products to protect the skin from exposure to chemicals and irritants. Generally, the mechanism of action of such products is mainly due to the formation of a superficial thin film between the skin and the irritant or sensitizer, thus reducing or totally blocking the cutaneous penetration of such agents. Specifically, studies focusing on the effectiveness of commercial protective creams to prevent nickel cutaneous penetration are extremely scarce. The aim of the current work, therefore, is to evaluate the protective role of a commercially available barrier cream for nickel and compare the results with a simple moisturizing, following exposure to Ni powder.MethodsMarketed BCs were evaluated and tested. Human skin absorption of Ni was studied in vitro using static Franz diffusion cells.ResultsOur results demonstrate that the application of both formulations caused a reduction of Ni inside the skin (8.00 ± 3.35 μg·cm‐2 for the barrier cream and 22.6 ± 12.6 μg·cm‐2 for the general moisturizing product), with the specialized barrier cream being statistically (p = 0.015) more efficient on forming a protective barrier, thus evidencing the importance of some ingredients of such formulations on the nickel dermal accumulation.ConclusionsThe composition of the formulations based on film forming or chelating agents may play an imperative role to reduce the cutaneous penetration of Ni.

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Transdermal permeation of inorganic cerium salts in intact human skin

Cited by 2 publications

References 42 publications

Evaluating the Role of Protective Creams on the Cutaneous Penetration of Ni Nanoparticles

Evaluating the Role of Protective Creams on the Cutaneous Penetration of Ni Nanoparticles

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

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