Transdermal treatment of the surgical and burned wound skin via phytochemical-capped gold nanoparticles

Thermoresponsive gels containing gold nanoparticles (AuNPs) were prepared using Pluronic®127 alone (F1) and with hydroxypropyl methylcellulose (F2) at ratios of 15% w/w and 15:1% w/w, respectively. AuNPs were evaluated for particle size, zeta-potential, polydispersity index (PDI), morphology and XRD pattern. AuNP-containing thermoresponsive gels were investigated for their gelation temperature, gel strength, bio-adhesive force, viscosity, drug content, in vitro release and ex-vivo permeation, in addition to in vitro antibacterial activity against bacteria found in burn infections, Staphylococcus aureus. In vivo burn healing and antibacterial activities were also investigated and compared with those of a commercial product using burn-induced infected wounds in mice. Spherical AuNPs sized 28.9–37.65 nm displayed a surface plasmon resonance band at 522 nm, a PDI of 0.461, and a zeta potential of 34.8 mV with a negative surface charge. F1 and F2 showed gelation temperatures of 37.2 °C and 32.3 °C, bio-adhesive forces of 2.45 ± 0.52 and 4.76 ± 0.84 dyne/cm2, viscosities of 10,165 ± 1.54 and 14,213 ± 2.31 cP, and gel strengths between 7.4 and 10.3 sec, respectively. The in vitro release values of F1 and F2 were 100% and 98.03% after 6 h, with permeation flux values of (J1) 0.2974 ± 2.85 and (J2) 0.2649 ± 1.43 (µg/cm2·h), respectively. The formulations showed antibacterial activity with the highest values for wound healing properties, as shown in vivo and by histopathological studies. This study demonstrates that a smart AuNPs thermoresponsive gel was successful as an antibacterial and wound healing transdermal drug delivery system.

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“…J. Lee et al . 82 successfully produced biocompatible AuNPs used in skin recovery and wound healing through a transdermal delivery method.…”

Section: Discussionmentioning

confidence: 99%

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

Arafa

El-Kased

Elmazar

2018

Sci Rep

191

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“…Studies have shown the ability of gold nanoparticles to transiently open the stratum corneum and as a consequence increase the absorption of antioxidant and anti-inflammatory components added to the mixture to accelerate wound healing [178]. Another study, by Lee et al made use of gold nanoparticles in combination with phytochemicals to increase particle stability without cytotoxic side effects that are often encountered when chemical stabilizers are used [179]. Similar to the previously mentioned work, these phytochemicals also possess anti-inflammatory and antioxidative properties.…”

Section: Passive Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems and materials for wound healing applications

Saghazadeh

Rinoldi

Schot

et al. 2018

Advanced Drug Delivery Reviews

619

434

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Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

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“…The inflammatory reaction in wounded skin of rats was investigated in a recent report. Phytochemically stabilized Au NPs accelerate wound healing in a process that involves alteration of the amounts of TGF-β1, vascular endothelial growth factor (VEGF), and the number of mast cells in the wounded skin sections compared to vehicle controls (31, 32). These observations indicate an involvement of the particles in type 2 immune functions during the healing process.…”

Section: Wound Healingmentioning

confidence: 99%

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

et al. 2017

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The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.

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Transdermal treatment of the surgical and burned wound skin via phytochemical-capped gold nanoparticles

Cited by 45 publications

References 61 publications

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

Drug delivery systems and materials for wound healing applications

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

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