Transdiagnostic Internet treatment for anxiety disorders: A randomized controlled trial

Titov, Nickolai; Andrews, Gavin; Johnston, Luke; Robinson, Emma; Spence, Jay

doi:10.1016/j.brat.2010.05.014

Cited by 150 publications

(140 citation statements)

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“…Campbell et al (2012) and Titov et al (2010) only reported ITT sample results and both had relatively high attrition rates (17% & 16% respectively); therefore their results may have been biased and should be viewed with caution. The remaining three studies using the LOCF method (Leichsenring et al, 2009;Robinson et al, 2010;Steinmetz et al, 2011) had relatively low attrition rates (8%, 7% and 5.5% respectively) therefore the risk of bias was quite low for these studies.…”

Section: Quality Of Statistical Analysismentioning

confidence: 99%

“…Four of these studies assessed Internet-based cognitive behaviour therapy (iCBT) against other internet-based treatments (Andersson et al, 2012;Paxling et al, 2011;Robinson et al, 2010;Titov, Andrews, Johnston, Robinson, & Spence, 2010); whilst the other study assessed a web tool (My Disaster Recovery website) which was developed specifically for survivors of Hurricane Table 1.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…In the studies in which ITT analysis was performed, nine studies (Campbell et al, 2012;Jain et al, 2007;Leichsenring et al, 2009;Robinson et al, 2010;Steinmetz et al, 2011;Titov et al, 2010;Vollestad et al, 2011;Watkins et al, 2011;Watkins et al, 2012) employed the LOCF method for data imputation; and five of these studies (Campbell et al, 2012;Jain et al, 2007;Titov et al, 2010;Vollestad et al, 2011;Watkins et al, 2012) had an attrition rate of greater than 10 percent. However, Jain et al (2007) and Vollestad et al (2011) evidenced best practice by reporting results for both 'completer' and ITT samples providing assurance that the attrition rate did not compromise reported results; and Watkins et al (2011) and Watkins et al (2012) conducted sensitivity analysis to ensure that drop-outs did not adversely affect their results.…”

Section: Quality Of Statistical Analysismentioning

confidence: 99%

“…Six of these studies assessed treatments with a cognitive behaviour therapy (CBT) focus against either a waitlist control condition or other treatments (Andersson et al, 2012;Leichsenring et al, 2009;Paxling et al, 2011;Robins et al, 2012;Robinson et al, 2010;Titov et al, 2010;Westra et al, 2009). Out of these studies, four delivered their interventions via the Internet; while the other two studies delivered their interventions via individual face-to-face sessions (Leichsenring et al, 2009;Westra et al, 2009).…”

Section: Effects Of Treatment On Self-reported Worrymentioning

confidence: 99%

“…Furthermore, these differences were maintained at three month and 18 month follow-up. Paxling et al (2011) and Titov et al (2010) evaluated eight-week iCBT programmes against a waitlist control condition and found that worry was significantly reduced in those participants taking part in the iCBT programme in comparison to the waitlist control condition. Furthermore, these gains were maintained at follow-up: at three months , at 12 months and at three years (Paxling et al, 2011).…”

Section: Effects Of Treatment On Self-reported Worrymentioning

confidence: 99%

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Assessing treatments used to reduce rumination and/or worry: A systematic review

Querstret

Cropley

2013

Clinical Psychology Review

196

112

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Perseverative cognitions such as rumination and worry are key components of mental illnesses such as depression and anxiety. Given the frequent comorbidity of conditions in which rumination and worry are present, it is possible they are underpinned by the same cognitive process. Furthermore, rumination and worry appear to be part of a causal chain that can lead to long-term health consequences, including cardiovascular disease and other chronic conditions. It is important therefore to understand what interventions may be useful in reducing their incidence. This systematic review aimed to assess treatments used to reduce worry and/or rumination. As we were interested in understanding the current treatment landscape, we limited our search from 2002-2012. Nineteen studies were included in the review and were assessed for methodological quality and treatment integrity. Results suggested that mindfulness-based and cognitive behavioural interventions may be effective in the reduction of both rumination and worry; with both Internet-delivered and face-to-face delivered formats useful. More broadly, it appears that treatments in which participants are encouraged to change their thinking style, or to disengage from emotional response to rumination and/or worry (e.g., through mindful techniques), could be helpful. Implications for treatment and avenues for future research are discussed.

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Section: Quality Of Statistical Analysismentioning

confidence: 99%

Section: Description Of Included Studiesmentioning

confidence: 99%

Section: Quality Of Statistical Analysismentioning

confidence: 99%

Section: Effects Of Treatment On Self-reported Worrymentioning

confidence: 99%

Section: Effects Of Treatment On Self-reported Worrymentioning

confidence: 99%

See 3 more Smart Citations

Assessing treatments used to reduce rumination and/or worry: A systematic review

Querstret

Cropley

2013

Clinical Psychology Review

196

112

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Psychotherapies for Generalized Anxiety Disorder in Adults

Papola,

Miguel,

Mazzaglia

et al. 2024

JAMA Psychiatry

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ImportanceGeneralized anxiety disorder (GAD) is one of the most common mental disorders in adults. Psychotherapies are among the most recommended treatments for GAD, but which should be considered as first-line treatment needs to be clarified.ObjectiveTo use a network meta-analysis to examine the short- and long-term associations of different psychotherapies with outcomes of effectiveness and acceptability in adults with GAD.Data SourcesMEDLINE, Embase, PsycINFO, and the Cochrane Register of Controlled Trials were searched from database inception to January 1, 2023, to identify randomized clinical trials (RCTs) of psychotherapies for adults with GAD.Study SelectionRCTs comparing any type of psychotherapy against another or with a control condition for the treatment of adults (≥18 years, both sexes) with a primary diagnosis of GAD were eligible for inclusion.Data Extraction and SynthesisThis study followed Cochrane standards for extracting data and assessing data quality and used the PRISMA guideline for reporting. Risk of bias of individual studies was assessed using the second version of the Cochrane risk of bias tool, and the Confidence in Network Meta-Analysis was used to rate the certainty of evidence for meta-analytical results.Main Outcomes and MeasuresEight psychotherapies were compared against one another and with 2 control conditions. Primary outcomes were severity of GAD symptoms and acceptability of the psychotherapies. Random-effects model pairwise and network meta-analyses were conducted. For effectiveness, standardized mean differences (SMDs) were pooled, and for acceptability, relative risks with 95% CIs were calculated.ResultsData from 66 RCTs were included. Effect size estimates on data from 5597 participants (mean [SD], 70.9% [11.9%] women; mean [SD] age, 42.2 [12.5] years) suggested that third-wave cognitive behavior therapies (CBTs) (SMD, −0.78 [95% CI, −1.19 to −0.37]; certainty, moderate), CBT (SMD, −0.68 [95% CI, −1.05 to −0.32]; certainty, moderate), and relaxation therapy (SMD, −0.54 [95% CI, −1.04 to −0.05]; certainty, low) were associated with reduced GAD symptoms vs treatment as usual. Relative risks for all-cause discontinuation (indication of acceptability) signaled no differences compared with treatment as usual for all psychotherapies (eg, relative risk, 1.07 [95% CI, 0.73-1.57] for CBT vs treatment as usual). When excluding studies at high risk of bias, relaxation therapy lost its superiority over treatment as usual (SMD, −0.40; 95% CI, −1.15 to 0.34). When considering anxiety severity at 3 to 12 months after completion of the intervention, only CBT remained significantly associated with greater effectiveness than treatment as usual (SMD, −0.58; 95% CI, −0.93 to −0.23).Conclusions and RelevanceGiven the evidence in this systematic review and network meta-analysis for its associations with both acute and long-term effectiveness, CBT may represent the first-line therapy of GAD. Third-wave CBTs and relaxation therapy were associated with short-term effectiveness and may also be offered.

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Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults

Mayo‐Wilson

Montgomery

2013

Cochrane Database of Systematic Reviews

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Transdiagnostic Internet treatment for anxiety disorders: A randomized controlled trial

Cited by 150 publications

References 48 publications

Assessing treatments used to reduce rumination and/or worry: A systematic review

Assessing treatments used to reduce rumination and/or worry: A systematic review

Psychotherapies for Generalized Anxiety Disorder in Adults

Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults

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