Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma

Kuang, Xuejun; Zhu, Jinmin; Zhao, Peng; Wang, Jianjun; Chen, Zhigang

doi:10.1007/s10620-015-3879-2

Cited by 19 publications

(20 citation statements)

References 27 publications

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“…Thus, it is critical to take measures to predict and reduce tumor recurrence. So far, previous studies have shown that tumor recurrence after surgical resection could be predicted by many tumor‐related factors, including tumor properties histological characteristics and inflammation‐related markers …”

Section: Introductionmentioning

confidence: 99%

Lymphocyte to monocyte ratio and neutrophil to lymphocyte ratio are superior inflammation‐based predictors of recurrence in patients with hepatocellular carcinoma after hepatic resection

Yang

Zhu

Zhao

et al. 2017

Journal of Surgical Oncology

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Section: Introductionmentioning

confidence: 99%

Lymphocyte to monocyte ratio and neutrophil to lymphocyte ratio are superior inflammation‐based predictors of recurrence in patients with hepatocellular carcinoma after hepatic resection

Yang

Zhu

Zhao

et al. 2017

Journal of Surgical Oncology

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“…In prostate cancer, TBL1XR1 was reported to function as a tumor suppressor and inhibit tumor growth, perhaps through regulating androgen receptor (AR) signaling pathway (Daniels et al 2014. However, TBL1XR1 has been reported to be highly expressed in cervical cancer , breast cancer , nasopharyngeal carcinoma , hepatocellular carcinoma (Kuang et al 2016), digestive cancers (Liu et al 2016a;Zhou et al 2016;Liu et al 2017), and ovarian cancer . However, the significance of TBL1XR1 in predicting clinical outcomes of EOC patients has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Over-Expression of TBL1XR1 Indicates Poor Prognosis of Serous Epithelial Ovarian Cancer

2017

Tohoku J. Exp. Med.

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Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) is a core component of the NCoR/SMRT transcription co-repressor complex, and its role in regulating cancer progression has been reported. Serous epithelial ovarian cancer (EOC) is the most common histological type of EOC. Here we explored the significance of TBL1XR1 expression in predicting outcomes of patients with serous EOC. Real-time quantitative PCR analysis showed that the expression level of TBL1XR1 mRNA was significantly higher in EOC tissues compared with adjacent non-tumorous tissues. The protein levels of TBL1XR1 in EOC tissues were assessed by immunohistochemistry, and the patients were classified into low-expression group (n = 62) and high-expression group (n = 54) according to the immunoreactivity. Prognostic significance of TBL1XR1 was evaluated by univariate and multivariate analyses, showing that over-expression of TBL1XR1 was correlated with poor prognosis. In addition, TBL1XR1 was positively associated with the lymph node metastasis of EOC. Because vascular endothelial growth factor (VEGF)-C is known as a critical mediator of lymph node metastasis, we measured the expression level of VEGF-C mRNA in EOC tissues and thus identified a positive correlation between TBL1XR1 and VEGF-C mRNA levels. Subsequently, using human EOC cell lines, we showed that silencing of TBL1XR1 decreased VEGF-C expression, suggesting that TBL1XR1 may function as an upstream regulator of VEGF-C in EOC. Furthermore, the proliferation and invasion of EOC cells were inhibited by TBL1XR1 silencing. In conclusion, TBL1XR1 overexpression may be an unfavorable prognostic factor for EOC. We also suggest that the TBL1XR1-VEGF-C axis may determine the EOC progression.

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“…High expression of TBL1XR1 mRNA exists widely in thyroid, breast and other human tissues . It is reported that TBL1XR1 also contributes to carcinogesis and tumour progression in cervical cancer, gastric cancer and hepatocellular carcinoma . Deletion of TBL1XR1 reduced the proliferation, invasion and resistance to therapy .…”

Section: Introductionmentioning

confidence: 99%

Exosomal miR‐103a‐3p ameliorates lipopolysaccharide‐induced immune response in BEAS‐2B cells via NF‐κB pathway by targeting transducin β‐like 1X related protein 1

Liang

Yuan

et al. 2020

Clin Exp Pharma Physio

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Abnormal immune response contributes to pathophysiology of pneumonia and is recognized as a main factor for high incidence rate in children. The association between exosomes and inflammation has been reported in diverse cell types and diseases. The current study focuses on exploring the effects of exosomal miR‐103a‐3p on lipopolysaccharide (LPS)‐induced inflammation, and investigates the underlying mechanisms. We proved that miR‐103a‐3p was lowly expressed in blood samples of pneumonia patients and LPS‐induced lung cells, and overexpression of miR‐103a‐3p weaken the LPS‐induced inflammation. Using luciferase reporter assay and immunoprecipitation assay, we demonstrated that miR‐103a‐3p directly binds to a specific region of transducin β‐like 1X related protein 1 (TBL1XR1), mediating the NF‐κB signalling pathway, thus regulating immune response. Taken together, our data revealed that miR‐103a‐3p functions as an anti‐inflammatory gene in childhood pneumonia and can be applied as therapeutic targets for the treatment of childhood pneumonia in the future.

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Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma

Abstract: Our finding suggested that TBLR1 is likely to be a potential prognostic indicator and therapeutic target for HCC and that TBLR1 may be implicated in EMT of HCC cells.

Cited by 19 publications

References 27 publications

Lymphocyte to monocyte ratio and neutrophil to lymphocyte ratio are superior inflammation‐based predictors of recurrence in patients with hepatocellular carcinoma after hepatic resection

Lymphocyte to monocyte ratio and neutrophil to lymphocyte ratio are superior inflammation‐based predictors of recurrence in patients with hepatocellular carcinoma after hepatic resection

Over-Expression of TBL1XR1 Indicates Poor Prognosis of Serous Epithelial Ovarian Cancer

Exosomal miR‐103a‐3p ameliorates lipopolysaccharide‐induced immune response in BEAS‐2B cells via NF‐κB pathway by targeting transducin β‐like 1X related protein 1

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