Transduodenal surgical ampullectomy for intra-ampullary papillary tubular neoplasm (IAPN): A case report

Pradhan, Shreeti; Adhikari, Krishna Mohan; Dahal, Ranjan Kumar; Pradhan, Sumita; Bhandari, Ramesh Singh

doi:10.1016/j.ijscr.2021.106253

Cited by 2 publications

References 10 publications

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Transduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct

Wang,

Yang

et al. 2024

Eur J Med Res

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Background The clinical diagnosis and treatment of dilation of the cholangiopancreatic duct in patients with ambiguous ampullary disease, termed unexplained dilation of the cholangiopancreatic duct (UDCD), is commonly difficult. This study aimed to evaluate the applicability of transduodenal ampullectomy (TDA) for the diagnosis and treatment of UDCD. Methods We first proposed a surgical exploration procedure based on the TDA and applied it in a representative UDCD patient. We retrospectively analyzed the pathological diagnosis and prognosis of 14 patients at our hospital and 189 patients reported in existing studies who were treated with TDA between January 2010 and December 2022. Results TDA can be used to radically explore the ampullary region and harvest adequate pathological tissue, which is helpful for identifying the cause of UDCD. The diagnostic rate of intraoperative frozen pathology was greater than that of preoperative endoscopic biopsy (78.41% vs. 65.94%, P = 0.044). The postoperative complication rate was 27.07%, with a mortality rate of 0.00%. The 5-year survival rate was 68.31% in patients with adenocarcinoma, 85.99% in patients with adenoma with HGD/pTis, and 100% in patients with benign lesions, and these had a statistically significant difference ( P = 0.021). Conclusions TDA-based surgical exploration can be used as a safe and effective transitional procedure in the treatment of UDCD. Supplementary Information The online version contains supplementary material available at 10.1186/s40001-024-02144-4.

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Transduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct

Wang,

Yang

et al. 2024

Eur J Med Res

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Transduodenal ampullectomy is an effective surgical exploration procedure in unexplained dilation of cholangiopancreatic duct

Wang

et al. 2023

Preprint

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Background The dilation of cholangiopancreatic duct with ambiguous ampullary diseases, named unexplained dilation of cholangiopancreatic duct (UDCD), is a common difficulty in clinical diagnosis and treatment. This study aims to evaluate the applicability of transduodenal ampullectomy (TDA) in the diagnosis and treatment of UDCD. Methods We first proposed the surgical exploration procedure based on TDA and applied it in a representative UDCD patient. Then we retrospectively analyzed the pathological diagnosis and prognosis of 14 patients at our hospital and 181 patients reported by existing studies, who were treated with TDA between January 2010 and December 2022. Results TDA could radically explore the ampullary region and harvest adequate pathological tissue, which was helpful for discovering the cause of UDCD. The diagnostic rate of intraoperative frozen pathology was higher than that of preoperative endoscopic biopsy (78.65% vs 66.42%, P = 0.047). The postoperative complication rate was 31.45%, with mortality 0%. The 5-year survival rate was 72.5% in patients with adenocarcinoma, 91.9% in adenoma with HGD/pTis, and 100% in benign lesions, which have statistically significant difference (P = 0.012). Conclusions TDA-based surgical exploration can be used as a safe and effective transitional procedure in the treatment of UDCD.

show abstract

Transduodenal surgical ampullectomy for intra-ampullary papillary tubular neoplasm (IAPN): A case report

Cited by 2 publications

References 10 publications

Transduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct

Transduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct

Transduodenal ampullectomy is an effective surgical exploration procedure in unexplained dilation of cholangiopancreatic duct

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