Transepithelial elimination in cutaneous sarcoidosis

Abstract

A patient known to have sarcoidosis exhibited cutaneous lesions. Microscopic examination of serial sections showed histologic evidence of transepithelial elimination of the sarcoidal granuloma. The concept and possible mechanisms of transepithelial elimination are discussed.

The granulomatous reaction pattern

“…158 In some cases the round cell infiltrate surrounding the granulomas is more intense and the granulomas less discrete. 158 In some cases the round cell infiltrate surrounding the granulomas is more intense and the granulomas less discrete.…”

Transepithelial elimination in sarcoidosis: a frequent finding

“…Sarcoidosis with histopathologic evidence of transepithelial elimination was previously considered a rare phenomenon, with six cases described in the English literature . Additionally, three cases have been described in the foreign literature, but are not detailed in this article .…”

“…But even this is not an all‐inclusive list. The nature of the eliminated material is less important than its location within the dermoepithelial ‘interaction range’ …”

“…Cutaneous sarcoidosis with histopathologic evidence of transepithelial elimination was previously considered a rare phenomenon, with six cases described in the English literature to date . We begin by describing a case of cutaneous sarcoidosis with histopathologic evidence of transepithelial elimination and also complete a review of the English literature regarding this phenomenon.…”

Perforating granuloma annulare presenting on the ears

“…The differential diagnosis of PGA includes other transepithelial elimination disorders such as Kyrle's disease, elastosis perforans serpiginosa, perforating collagenosis, perforating folliculitis and perforating papules of diabetic dialysis patients, molluscum contagiosum, and sarcoidosis. There have been three reports of sarcoidosis with transepithelial elimination 9 …”