Percutaneous closure of paravalvular leaks has been reported in patients who are poor operative candidates. Transesophageal echocardiography (TEE) currently plays an important role in procedures of this kind. TEE provides essential information regarding the characteristics of the dehiscence, periprosthetic regurgitation severity, during the intervention, procedure-related complications, immediate result of the procedure, and long-term follow-up. Also, three-dimensional TEE enables us to determine the location and number of the leaks, its shape, length, width, area, and extent, and would improve the ascertainment of the causes underlying failure of these techniques to reduce regurgitation secondary to the defect. All of this information could improve patient selection and results of this procedure in the future.