Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives

Micelle-modulated reactivity of novel copper(ii) complexes with reduced l-histidine Schiff bases as mimic carboxylesterases

“…20–22 Some studies concerning imidazole derivatives have mainly focused on their structural and physical properties, however, few studies explored their biological functions of imidazole derivatives. 23–26 In previous reports, 27–29 metal complexes with certain imidazole derivatives have exhibited promising hydrolase activity. Reduced amino acid Schiff bases offered the advantage of increased stability under acidic and basic conditions in addition to greater flexibility.…”

“…[20][21][22] Some studies concerning imidazole derivatives have mainly focused on their structural and physical properties, however, few studies explored their biological functions of imidazole derivatives. [23][24][25][26] In previous reports, [27][28][29] metal complexes with certain imidazole derivatives have exhibited promising a School of Chemistry and Environmental Engineering, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science & Engineering, Sichuan Zigong 643000, P. R. China. E-mail: jwdxb@suse.edu.cn, xbjwd@suse.edu.cn b Small Molecule Division, Porton Pharma Solutions Ltd., Chongqing Beibei 400700, P. R. China † Electronic supplementary information (ESI) available: 1 H NMR spectrum of ligand HL 1 (600 MHz, deuterium oxide À20% HCl); 1 H NMR spectrum of ligand HL 2 (600 MHz, deuterium oxide À20% HCl); the EPR spectrum of complexes 1 and 2 at room temperature; the measured and simulated XRD by mercury for complexes 1 and 2; the relative activity between 2 and 1 for the PNPA catalytic hydrolysis; ESI + -MS spectra for complex 1 in H 2 O medium; ESI + -MS spectra for complex 2 in H 2 O medium; pH-dependent hydrolysis of PNPA promoted by 1 in micellar solutions of 16-6-16 (A), LSS (B), and C 22/8 (C); UV-vis spectra for the hydrolysis of PNPA or PNPP (inset) by 1; selected bond length (Å) of 1 and 2; selected bond angle (1) of 1 and 2; calculated Addison tau factors (t) and geometry for central copper(II) ions of 1 and 2; pseudo first-order rate constants of PNPP hydrolysis catalysed by 1 or 2 in buffered aqueous solution; apparent first-order rate constants of PNPA mediated by 2 in various micelles; apparent first-order rate constants of PNPA mediated by 1 in various micelles.…”