This report presents the case of an 82 year old male with known dextrocardia and situs inversus totalis who developed increasing dyspnea on exertion and was diagnosed with severe aortic stenosis. Transcatheter aortic valve replacement was decided upon requiring deviation from standard techniques for patients with normal anatomy and left-sided aortic arch. We describe two technical differences required for patients with dextrocardia and right-sided aortic arch which facilitate transcatheter aortic valve replacement in this patient group. Dextrocardia is a condition in which there is abnormal embryological looping of the heart such that it is a mirror-image of the usual anatomy. It occurs in less than 1 in 10,000 births and it may be associated with either situs solitus, in which the rest of the organs of the body are in their normal anatomic position, or situs inversus totalis in which all of the body's organs are in a mirror-image position. Although dextrocardia is associated with other congenital cardiac anomalies as well as Kartagener's syndrome it does not usually impair physiology itself thereby allowing many patients to live a normal lifespan.