Transfer Factor as an Additional Therapeutic Agent in Mycosis Fungoides

Dialyzable Leukocyte Extract Stimulates cAMP in Tγ Lymphocytes

“…The clinical observation of increased skin augment delayed hypersensitivity reactions in reactivity and lymphokine production after the skin (10). DLE therapy in patients with DLE therapy (7,11), and augmentation of evidence of depressed cell-mediated immune DNA synthesis following in vivo (23) and in vitro reactitivity have shown promising clinical ef-(1) administration possibly reflect that DLE fects (7,19,20,23,25,26). However, the modulates the lymphocyte cyclic nucleotide syschemical constitution of transfer factor in DLE tem.…”

T- and B-cells and IgE in mycosis fungoides

“…and this could have bear ing on therapy. Our patient with the lowest T-cell value also had a poor response in lyrnphocyte trans formation tests (14). This patient was treated with transfer factor as an additional t herapeutic agent when he did not respond to conventional treatment with topical nitrogen mustard, methotrexate, X-rays and grenz rays.…”

Long‐term Transfer Factor Treatment in Severe Atopic Dermatitis

“…Also, we could not demonstrate any correlation between the presence of "migration-inhibition-factor" in serum and the increased inhibition of leucocyte migration occasionally seen after addition of PPD to tbe cultures. TF, prepared in the same way as in this trial, has earlier been used successfully in our department for tbe treatment of mycosis fungoides (21) and in a patient witb generalized M. avium infection (17). However, in the present study no lasting effect witb TF treatment was recorded in the in vitro investigations and only minor clinical improvements were obtained.…”

“…at intervals of a to 4 weeks. TF was prepared from pooled buffy coat cells from normal blood donors (21).…”

“…In dermatology TF has been successfully used to intensify parameters of cell-mediated immune reactions in a patient with severe skin infection caused by Mycobacterium avium (17); also in generalized vaccinia treatment with TF seems to be of value (5). In mycosis fungoides additional treatment with TF was found promising (21).…”