Transfer Factor in Mycosis fungoides: Three Years Experience

Abstract

13 patients with clinically and histologically verified mycosis fungoides were treated with transfer factor as additional therapy to the hitherto conventional treatment after this had failed. After approximately 3 years, complete remission was present in 3 patients, 4 patients were significantly improved and registered as being in partial remission, while the condition was registered as no change in 3 patients. 1 patient was found worse, 1 patient had died after discontinuation of therapy and 1 patient was out of the study. In this case treatment was withdrawn because of the development of contact urticaria to nitrogen mustard, her basic therapy. The number of T lymphocytes, which was low prior to treatment, increased to normal values during the therapeutic period. During the first year a decrease in serum IgE was noted. The results of the clinical evaluation seem to indicate that transfer factor may be of value as an additional therapeutic agent in mycosis fungoides. Controlled investigations are needed and are in progress.

Dialyzable Leukocyte Extract Stimulates cAMP in Tγ Lymphocytes

“…T lymphocytes with Fc receptors for IgG are believed to express suppressor T cell functions (12). Thus, longterm DLE therapy to patients with mycosis fungoides was parallelled by a significant fall in the concentration of IgE in serum and an increase in percentage of T lymphocytes in peripheral blood (25). Thus, longterm DLE therapy to patients with mycosis fungoides was parallelled by a significant fall in the concentration of IgE in serum and an increase in percentage of T lymphocytes in peripheral blood (25).…”

“…Suppressor T cells have regulatory functions for reaginic antibody production (22). Thus, longterm DLE therapy to patients with mycosis fungoides was parallelled by a significant fall in the concentration of IgE in serum and an increase in percentage of T lymphocytes in peripheral blood (25). In one patient with severe atopic dermatitis, high IgE level and low T cell percentage reversed following DLE administration (20).…”

“…The clinical observation of increased skin augment delayed hypersensitivity reactions in reactivity and lymphokine production after the skin (10). DLE therapy in patients with DLE therapy (7,11), and augmentation of evidence of depressed cell-mediated immune DNA synthesis following in vivo (23) and in vitro reactitivity have shown promising clinical ef-(1) administration possibly reflect that DLE fects (7,19,20,23,25,26). However, the modulates the lymphocyte cyclic nucleotide syschemical constitution of transfer factor in DLE tem.…”

Mycosis fungoides plaque stage treated with topical nitrogen mustard with and without attempts at tolerance induction: report from the Scandinavian mycosis fungoides study group

“…or until re lapse, when intensified nitrogen mustard treatment was given. However, some patients in relapse were referred to a phase 2 study in which transfer factor was combined with the topical nitrogen mustard (12). lf the disease prog ressed 10 tumour stage, systemic chemotherapy was given according 10 other treatment modalities in the Scandina vian Mycosis Fungoides Study Group (2).…”