Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Shii, Daisuke; Oda, Tomoko; Nakamura, Masatsugu

doi:10.1097/ico.0b013e3181b442d0

Cited by 1 publication

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“…Th2 cells produce IL-4 and IL-5 cytokines, which may induce eosinophil growth and activation in VKC. Activated eosinophils produce cytotoxin proteins like ECP, EPa and MBP which could be directly involved in corneal damage (26). Both corticosteroids and cyclosporine A induce Th 1 and Th2 cell suppression leading to a consequent reduction of eosinophilic activity.…”

Section: Discussionmentioning

confidence: 99%

Surgical Debridement Plus Topical Cyclosporine a in the Treatment and Vernal Shield Ulcers

Caputo

Pucci

Mori

et al. 2012

Int J Immunopathol Pharmacol

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Vernal keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6% develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of punctate keratitis, shield ulcers (3-11%) and late corneal neovascularization. In recent years, topical cyclosporine A preparations at 2% in oil or at 1% in polyvinyl alcohol, have been successfully proposed for long term VKC treatments. It has been previously proven that medical treatment is not always sufficient, especially when it is employed to treat shield ulcer plaques. In such conditions, surgery may be effective for avoiding long term complications such as amblyopia, strabismus, infections and corneal perforation. In this paper, we show the efficacy of surgical debridement by means of simple scraping associated with topical cyclosporine treatment for the management of vernal shield ulcers complicated with plaques.

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Section: Discussionmentioning

confidence: 99%

Surgical Debridement Plus Topical Cyclosporine a in the Treatment and Vernal Shield Ulcers

Caputo

Pucci

Mori

et al. 2012

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

Transfer of a T-helper Type 2 Clone Into Conjunctiva Induces Corneal Damage in Mice

Abstract: The transfer of the Th2 clone into the murine conjunctiva induced corneal damage, which may have been caused by Th2 cell-produced interleukin-5 that mediated the activation of eosinophils.

Cited by 1 publication

References 28 publications

Surgical Debridement Plus Topical Cyclosporine a in the Treatment and Vernal Shield Ulcers

Surgical Debridement Plus Topical Cyclosporine a in the Treatment and Vernal Shield Ulcers

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