Transfer of Anti‐d Antibodies Across the Isolated Perfused Human Placental Lobule and Inhibition by High‐dose Intravenous Immunoglobulin: A Possible Mechanism of Action

Urbaniak, S. J.; Duncan, J. I.; Armstrong-Fisher, S.S.; Abramovich, D. R.; Page, K.R.

doi:10.1046/j.1365-2141.1997.8762507.x

Cited by 32 publications

(25 citation statements)

References 25 publications

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“…Women whose fetuses are at risk from hemolytic anemia (31) or neonatal idiopathic thrombocytopenic purpura (32) have also been treated successfully with intravenous IgG. This treatment may be particularly appropriate because it specifically competes with the maternal IgG for transfer across the placenta (36). Identification of an immune basis for any developmental disorder should be an indication for immunotherapy during subsequent pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice

Jacobson¹,

Polizzi²,

Morriss‐Kay³

et al. 1999

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice

Jacobson¹,

Polizzi²,

Morriss‐Kay³

et al. 1999

J. Clin. Invest.

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“…Several immunomodulatory mechanisms have been proposed for the action of high-dose IVIG in reducing the volume of fetal hemolysis [10] . In an in vitro perfusion model, IVIG has been noted to decrease the passage of maternal anti-D acting as a ligand for placental Fc γ receptors involved in the uptake of IgG [79] . Other proposed mechanisms include the blockade of activating Fc receptors, the induction of the surface expression of the inhibitory Fc γ -RIIB on splenic macrophages, and the inactivation of the FcRn receptor, which prevents the catabolism of IgG, resulting in increased catabolism of the harmful antibodies as well [90] .…”

Section: Intravenous Immunoglobulinmentioning

confidence: 99%

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Παπαντωνίου

Sifakis

Antsaklis

2012

Journal of Perinatal Medicine

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Fetal anemia, mainly due to red cell alloimmunization, is still a signifi cant cause of fetal and neonatal mortality and morbidity. The focus of current clinical research has shifted from an invasive approach to non-invasive management and treatment of affected pregnancies, and the progress in this fi eld is associated with a major improvement in perinatal outcome. During the last 50 years, intrauterine red cells transfusion (IUT), fi rst via the intraperitoneal route and later directly to fetal circulation, is the standard practice in most centers, with survival rates that exceed 90 % , particularly if anemia is diagnosed early and treated in a timely manner. In addition, plasmapheresis and intravenous administration of highdose immunoglobulin have been implicated in the treatment of pregnancies complicated with early-onset severe red cell alloimmunization, alone or in combination with IUTs before the 20 th week of pregnancy, but there are still issues to be clarifi ed further. This review article aims to provide an overview of the current standard therapeutic management and alternative treatment modalities in pregnancies complicated by fetal anemia.

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“…In general, IgG antibodies suppress the production of both IgM and IgG antibodies, whereas, specific antibodies tend to suppress a specific immune response better than non-specific antibodies, as seen in the method employed to prevent hemolytic disease of the newborn in human [27]. This is thought to be mainly due to the negative feedback mechanism produced by total circulating maternal IgG [22,28] or may be due to masking of antigenic epitopes [18,19,24], thereby removing the stimulus for proliferation of antibody producing cells. Our data in this paper indicates that the suppressive effect of antigen specific maternal antibodies on the immune response of newly hatched chicks depends mainly on the antigen/antibody ratio at the time of immunization.…”

Section: Discussionmentioning

confidence: 99%

Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody

Elazab

Fukushima

Fujita

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Prolonged interference or suppression of maternal antibodies of the humoral immune response of newly hatched chicks to active immunization has been documented; however, the immunological mechanisms responsible for such suppression are still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specific IgY antibodies were transferred by yolk sac inoculation to newly hatched chicks, and they were immunized with DNP-KLH or rabbit serum albumen (RSA) at 1 and 4 weeks of age. The concentrations of anti-DNP and anti-RSA antibodies in serum samples of these chicks were measured using an enzyme-linked immunosorbent assay (ELISA). The immune responses of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with an appropriate dose of DNP-KLH were suppressed. However, those of the chicks that received the same high dose of maternal non-specific IgY antibodies and were immunized with an appropriate dose of DNP-KLH and those of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with RSA were not suppressed. On the other hand, suppression of anti-DNP antibody production would not be induced if the chicks received a high dose of antigen specific maternal antibodies and were immunized with a high dose of the same antigen. These results revealed that the immune suppressive effect of maternal antibodies on the immune response of the newly hatched chicks was antigen specific and depended mainly on the ratio of antigen/maternal antibody at the time of immunization. Maternal derived antibodies provide immunological protection for newly hatched chicks against many environmental pathogens before active antibody production occurs. However, it has been found and reported that the presence of a high level of maternal antibodies can also interfere or suppress the ability of the young chick to actively respond to an early vaccination [6,13,21]. Prolonged interference or suppression of maternal antibodies of the humoral immune response of newly hatched chicks to active immunization has been documented [10]. It is also known that maternal IgG down-regulates neonatal Ig synthesis [20], perhaps by removing environmental antigens in the same manner as intravenous immunoglobulin treatment or through a direct effect on B cells. In humans and mice, the effect of maternal antibodies on early life responses has been widely studied. Most reports indicate that the presence of maternal antibodies further limits the intrinsic weakness of infant primary antibody responses to both natural infections and vaccinations [1]. The purpose of this study was to detect the antigen-specificity on the suppression by maternal antibodies and investigate the effect of the ratio of the antigen and maternal antibodies on the immune response of the newly hatched chick. MATERIALS AND METHODSAntigen preparation: A classical hapten-carrier antigen, dinitrophenylated keyhole limpet hemocyanin (DNP-KLH), was used and prepar...

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Transfer of Anti‐d Antibodies Across the Isolated Perfused Human Placental Lobule and Inhibition by High‐dose Intravenous Immunoglobulin: A Possible Mechanism of Action

Abstract: Summary. Using an in vitro

Cited by 32 publications

References 25 publications

Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice

Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody

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