Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP)

Schmidt, Cecilia L.; Ziegler, Dominique de; Gagliardi, Carol L.; Mellon, Richard W.; Taney, Frances H.; Kuhar, Mary Jeanne; Colon, J; Weiss, Gerson

doi:10.1016/s0015-0282(16)60973-1

Cited by 108 publications

(37 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vaginal P was seen as the last resort for finding an alternative to the painful side-effects of IM P injections. Pharmacy-compounded vaginal suppositories were used as sole support in the donor egg setting and for frozen embryo transfers (FETs) in the late 1980s (25). Later, pharmacologically prepared products were designed for vaginal administration of P, as discussed below.…”

Section: Progesterone Hcg or Gnrh-a Progesteronementioning

confidence: 99%

“…The high efficacy of hormonal regimens designed for priming endometrial receptivity in recipients of oocyte donation (21) has led to their widespread use for FETs (25). Contrary to what prevails in regular ART, there is no endogenous production of E 2 and P cycles, and endometrial receptivity depends on exogenously administered hormones.…”

Section: The Donor Egg Settingmentioning

confidence: 99%

See 1 more Smart Citation

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Ziegler

Pirtea

Andersen

et al. 2018

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

show abstract

Section: Progesterone Hcg or Gnrh-a Progesteronementioning

confidence: 99%

Section: The Donor Egg Settingmentioning

confidence: 99%

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Ziegler

Pirtea

Andersen

et al. 2018

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

show abstract

“…Embryo transfer is carried out according to the stage of the embryo. This method is effective (Table 3) [36][37][38][39] and there is a real cost savings when compared with artificial cycles. Patients can also have their embryos replaced during a hormone replacement treatment (HRT) cycle.…”

Section: Synchronization Of Thawing and Endometrial Preparationmentioning

confidence: 99%

Cryopreservation, Thawing, and Transfer of Human Embryos

Byrd¹

2002

Semin Reprod Med

View full text Add to dashboard Cite

Cryopreservation of human embryos is a routine procedure in most assisted reproductive technology laboratories. Embryos can be successfully frozen at the pronuclear, multicellular (four to eight blastomeres), and blastocyst stages. Each laboratory has to determine which freezing protocol is best suited for its patients. Freezing protocols have been developed that utilize cryoprotective agents such as glycerol, propanediol, dimethylsulfoxide, and sucrose. The purpose of these cryoprotectants is to help reduce the formation of intracellular ice when using a slow cooling protocol to freeze the embryos. The two most common ways to freeze embryos utilize either low concentrations of cryoprotectants and a slow stepwise freeze or high concentrations of cryoprotectants and a rapid freeze. Frozen-thawed embryos can be transferred to naturally cycling women or to women who have been primed with hormone replacement treatment with equal success.

show abstract

“…Contrasting with the findings just reported above, vaginal P administration has been remarkably effi cacious at inducing complete secretory transforma-tion of endometrial glands and stroma despite plasma P levels most commonly inferior to those of the menstrual cycle. 16 In early studies using P administered from cocoa butter base suppositories at the dose of 50 mg TID, plasma P levels were between 7 and 12 ng/mL. 16 Essentially similar plasma P levels were obtained when 200 to 300 mg of P were administered daily (1 or 2 doses) from an oil solution engulfed in soft gelatin capsules (Utrogestan, Besins-Iscovesco Pharmaceuticals, Paris).…”

Section: The Vaginal Route Paradox: Evidence For a First Uterine Passmentioning

confidence: 99%

Hormonal Strategies for Preparing the Human Endometrium Prior to Oocyte Donation

Ziegler¹

1995

Semin Reprod Med

View full text Add to dashboard Cite

Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP)

Cited by 108 publications

References 12 publications

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Cryopreservation, Thawing, and Transfer of Human Embryos

Hormonal Strategies for Preparing the Human Endometrium Prior to Oocyte Donation

Contact Info

Product

Resources

About