Transfer of Delayed Hypersensitivity in the Chicken

David, S.; Palladino, Michael A.; Romano, Tom; Thorbecke, G. J.

doi:10.1016/s0145-305x(82)80040-2

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…The results show that DTH could be transferred with lymphocytes-monocytes from peripheral blood or spleen. Chi et al (1982) similarly showed that DTH to adjuvated human gamma-globulin could be transferred between chickens by spleen cells or white blood cells. The need for MHC compatible macrophages and effector lymphocytes for DTH and related reactions is well documented in mammals (e.g.…”

Section: Discussionmentioning

confidence: 99%

The induction of delayed type hypersensitivity to dinitrochlorobenzene in the chicken

Huynh

Chubb

1987

Avian Pathology

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SUMMARYDelayed hypersensitivity to DNCB in chickens is a dose-dependent reaction. It could be induced by a single painting of the skin with 1 mg of DNCB/bird without adjuvant and could be elicited at a challenge site with 50 μg DNCB. The sensitisation lasted for several weeks, and was mediated by sensitised lymphoid cells which required the presence of autologous cells that adhered to plastic for the reaction to be transferred to other allogeneic birds. Doses above 1 mg/bird induced some form of suppression. The migration inhibition test could be used as an in vitro method to measure the DTH response and correlated with the DTH skin response.The histological appearance of skin lesions was characterised by the infiltration of a large number of granulocytes especially heterophils and some eosinophils, as well as large numbers of monocytes.

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Section: Discussionmentioning

confidence: 99%

The induction of delayed type hypersensitivity to dinitrochlorobenzene in the chicken

Huynh

Chubb

1987

Avian Pathology

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The avian basophilic leukocyte: a review

Maxwell

Robertson

1995

World's Poultry Science Journal

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Avian cellular immune effector mechanisms ‐ A review

Sharma

Tizard

1984

Avian Pathology

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Considerable new knowledge has accumulated within the last few years on the immune functions of birds, and data show that the avian cellular immune effector mechanisms are quite similar to those of mammals. Cellular immunity in the chicken, the most widely studied avian species, is primarily mediated by T cells, macrophages and NK cells. The avian T lymphocytes express unique surface antigens that distinguish these cells from other cells. The T cells respond vigorously in vitro to T cell-specific mitogens and can perform cytotoxic and mixed lymphocyte reactions against allogeneic or tumour cell targets. The in vivo responses mediated by T cells include allograft and tumour cell rejection, graft-versus-host reaction and delayed type hypersensitivity reactions. T cells also serve as helper cells in enabling B Cells to produce antibody against thymus-dependent antigens. Avian T cells also perform immune regulatory functions and sub-populations of T suppressor cells can cause profound blockage of antibody production by B cells. Certain T cell functions require cooperation from other immune cells, particularly major histo-compatibility complex-compatible macrophages. Avian macrophages resemble their mammalian counterparts in being adherent and phagocytic, and they serve as accessory cells in a multitude of immune reactions as well as effector cells in their own right. Macrophages when co-cultivated in vitro with tumour target cells may non-specifically arrest proliferation of tumour cells or lyse tumour cells. They may also engage in specific anti-alloantigen cytotoxicity following hyperimmunisation. Under certain circumstances, macrophages can also be potent suppressors of immune reactivity. Birds appear to have a well developed NK cell system. NK cells of chickens share general characteristics with mammalian NK cells and lack the surface markers of T cells, B cells, or macrophages. Recent evidence indicates that the NK cell system plays a role in defence against Marek's disease. NK-like cells have also been shown to mediate ADCC in chickens and ducks. The immunoregulatory factors that may mediate avian immune effector cell functions are currently being actively studied.

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Transfer of Delayed Hypersensitivity in the Chicken

Cited by 4 publications

References 11 publications

The induction of delayed type hypersensitivity to dinitrochlorobenzene in the chicken

The induction of delayed type hypersensitivity to dinitrochlorobenzene in the chicken

The avian basophilic leukocyte: a review

Avian cellular immune effector mechanisms ‐ A review

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