Transfer ofEimeria apionodesfrom wood mice (Apodemus sylvaticus) to laboratory mice (Mus musculus)

Abstract

Transfer of Eimeria apionodes from wood mice directly into untreated laboratory mice was unsuccessful but transfer into corticosteroid-treated animals produced an oocyst output, about 1000 times less than that observed from wood mice after a similar inoculum. Repeated passage through corticosteroid-treated laboratory mice resulted in a line adapted to survival in untreated animals. This line was compared with the parent strain maintained in wood mice and some features of the oocyst output patterns, notably the pre-patent period, appeared to be controlled by the host species. The oocyst production of each population was higher in the host species to which it was adapted than in the other host species (P less than 0.001). Once adapted to laboratory mice, the line produced insignificantly different levels of oocysts in corticosteroid-treated and untreated animals (P greater than 0.05).

Endogenous development, pathogenicity and host specificity of Eimeria cahirinensis Couch, Blaustein, Duszynski, Shenbrot and Nevo, 1997 (Apicomplexa: Eimeriidae) from Acomys dimidiatus (Cretzschmar 1826) (Rodentia: Muridae) from the Near East

“…Nowell and Higgs (1989) successfully transmitted E. apionodes Pellérdy 1954 and E. hungaryensis Levine and Ivens 1965 from Apodemus sylvaticus Linnaeus 1758 to corticosteroid-treated laboratory mice. Ibrahim and Nowell (1991) subsequently adapted E. apionodes to untreated mice by a series of passages to corticosteroid-treated mice. Thus, our third hypothesis tested was the ability of E. cahirinensis to infect a distant but immunocompromised rodent host.…”