Transfer of radioactive water, urea and glycine between maternal and foetal body fluids in rabbits and pigs

Stanier, Margaret W.

doi:10.1113/jphysiol.1965.sp007619

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Urea and creatinine are two such compounds that appear to move by diffusion and have been well studied by numerous investigators (9,17,20,22). Under constant infusion conditions neither 14C-creatinine nor 14C-urea were accu mulated by any of the fetal or placental tissues sampled to levels greater than in the maternal plasma (table IV) in keeping with a diffusional mechanism for transfer across the placentae.…”

Section: Discussionmentioning

confidence: 77%

Materno-Fetal Transport of Creatine in the Rat

Davis¹,

Miller²,

Brent³

et al. 1978

Neonatology

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The transfer of ¹⁴C-creatine to the rat fetus was studied following continuous i.v. infusion into the mother. In the presence of a relatively constant maternal plasma ¹⁴C-creatine concentration, creatine was accumulated by the chorioallantoic placenta and visceral yolk sac to concentrations higher than that found in maternal or fetal plasma. The ability of the extraembryonic membranes to accumulate creatine changed during gestation; nevertheless, these membranes concentrated creatine against a gradient throughout the period studied (14–22 days of gestation). Neither ¹⁴C-creatinine nor ¹⁴C-urea were concentrated in the placentae or fetal plasma when compared to maternal plasma. Simultaneous infusion of β-guanidinopropionic acid with ¹⁴C-creatine reduced both movement and accumulation of creatine into the fetoplacental unit. It is concluded that the accumulation of creatine by the chorioallantoic placenta and by the visceral yolk sac is an active process with creatine diffusing down its concentration gradient into the fetal circulation.

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Section: Discussionmentioning

confidence: 77%