Transfer of The Rat Tail: An Experimental Model for Free Osteocutaneous Transfer

Amara, B.; Fernandez, John J.; Newlin, Leonard; Buncke, Harry J.

doi:10.1055/s-2007-1000191

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…15 Though recommended by some, we believe that the tail model may be more useful as composite transplantation model or as a supermicrosurgery model in the distal tail. [16][17][18] The rat penile replant model in this study was the fastest replant procedure. It has comparable vessel sizes to the human digit but has the limitation of absence of the bony framework, tendons or muscles for coaptation.…”

Section: Discussionmentioning

confidence: 93%

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Digit Replantation Practice: A Comparison of Three Rat Models

Mofikoya

Ugburo

Belie

2023

Journal of Hand and Microsurgery

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Digit replantation is a complex surgery that nearly always needs to be done as an emergency. As such it is often difficult to teach. Several models have been developed to train surgeons in this procedure. We compare three rat models of replantation with the aim of ascertaining which most simulates the digit replantation. Inbred albino rats were selected and divided into three groups of 13 each, tail, penile, and hind replant groups. Three rats in each group were anesthetized, the specific amputation injury is created and is replanted for the anatomic component of the study. For the comparative section, 10 animals were anesthesized and the amputated parts were replanted under standard conditions. The parameters measured included weight, vessels and nerve diameters, method of fixation, total ischemia and replant times, the patency rates (after operation and at one week post surgery), as well as postoperative complications. All rats survived in the procedure. There was patency in all groups immediately. Rat tail group had 90%, penile group 100%, and hind limb group 90% survival 1 week after the replantation. There was one mortality in the hind limb group. The penile replant group was the shortest (p < 0.001), and all vessel sizes were comparable except the central artery of the tail which was significantly smaller (p < 0.001). The processes of the hind limb group most simulated the human digit replant procedure, though the ischemia and total replant times are significantly longer (p < 0.005). Though the immediate and 1 week patency rates were similar in all three groups, the hind limb replantation model involved steps most similar to human digit replant surgery and is recommended as the preferred teaching model.

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Section: Discussionmentioning

confidence: 93%

“…15 Though recommended by some, we believe that the tail model may be more useful as composite transplantation model or as a supermicrosurgery model in the distal tail. 16 17 18…”

Section: Discussionmentioning

confidence: 99%

Digit Replantation Practice: A Comparison of Three Rat Models

Mofikoya

Ugburo

Belie

2023

Journal of Hand and Microsurgery

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“…A number of studies have utilized live rat models to practice for replantation techniques by carrying out replantation of rat's tail (Zhang et al, ), penis(Karamürsel et al, ) and hindlimb (Ad‐El et al, ; Amara et al, ; Crainiceanu et al, n.d.). These skills involve amputation, tissue debridement, dissection of muscle, nerve and blood vessels, arterial and venous anastomosis along with nerve repair and skin suture.…”

Section: Live Animal Modelsmentioning

confidence: 99%

Current status of simulation and training models in microsurgery: A systematic review

et al. 2019

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With the prolific uptake of simulation-based training courses, this systematic review aims to identify the available microsurgical simulation and training models, their status of validation, associated studies, and levels of evidence (LoE) for each training model, thereby establishing a level of recommendation (LoR). MEDLINE, Embase, and the Cochrane Library databases were searched for English language articles, describing microsurgery simulators and/or validation studies. All studies were assessed for LoE, and each model was subsequently awarded a LoR using a modified Oxford Centre for Evidence-Based Medicine classification, adapted for education, with 1 being the highest and 4 the lowest score. A total of 86 studies were identified describing 64 models and simulators ranging from bench models, cadaveric animal tissue, cadaveric human tissue, live animal models, virtual reality simulators, and training curricula. Of these, 49 simulators had at least one validation study. Models were assessed for face (n = 42), content (n = 31), construct (n = 25), transfer (n = 10), and concurrent validity (n = 1) by these studies. The most commonly identified modality was bench models (n = 28) followed by cadaveric animal tissue (n = 24). The cryopreserved rat aorta model received the highest LoR followed by chicken wing, chicken thigh and practice cardboard models. Microsurgery simulation is a growing field and increasing numbers of models are being produced. However, there are still only a few validation studies with a high LoE. It is therefore imperative that training models and/or programs are evaluated for validity and efficacy in order to allow utilization in microsurgical skills acquisition.

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“…The CVA has prominent collateral circulation, and its caliber changes as it reaches the tail end [5]. Many studies investigating thermoregulation, microvascular surgery and ana-tomical structure have been performed by utilizing this vessel as an entire isolated vascular bed or as a small isolated dissected segment, [4][5][6][7][8][9][10][11]. Scientists have established and improved the chronic CVA cannulation technique under stress-free conditions in freely moving rats for up to 12 days [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Correction: Comparison of Invasive Blood Pressure Measurements from the Caudal Ventral Artery and the Femoral Artery in Male Adult SD and Wistar Rats

Wang¹,

Cong²,

Li³

et al. 2013

PLoS ONE

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Background and Purpose: Studies have suggested that the caudal ventral artery is a potential site for continuous arterial blood pressure monitoring in rats. However, the agreement of mean arterial pressure values between the femoral artery and the caudal ventral artery has not been investigated. This study was performed to identify whether the caudal ventral artery could be safely used for continuous blood pressure monitoring as an alternative site to the femoral artery.Methods: Rats were randomized into four groups: Sprague Dawley rats under normothermia; Wistar rats under normothermia; Sprague Dawley rats under hypothermia; Wistar rats under hypothermia. Each rat underwent simultaneous monitoring of blood pressure using femoral artery and caudal ventral artery catheterization during a stable hemodynamic state and three periods of acute severe hemodynamic changes. The effects of rat strain, rectal temperature, experimental time course and hemodynamic factors on pressure gradients, the concordance of mean arterial pressure values between the femoral artery and the caudal ventral artery, and the rates of distal ischemia after surgery were determined.Results: There was a significant difference in the rate of distal ischemia between femoral and caudal ventral arteries after catheterization (25% vs 5%, P,0.05). The overall mean gradient and the mean gradient under a steady hemodynamic state were 4.963.7 mm Hg and 5.562.5 mm Hg, respectively. The limits of agreement (bias61.96 SD) were (22.5 mm Hg, 12.3 mm Hg) and (-0.5 mm Hg, 10.5 mm Hg), respectively. Although the concordance decreased during the first 30 sec of each period of severe hemodynamic changes, the degree of agreement was acceptable regardless of the effects of rat strain and rectal temperature.Conclusions: Based on the degree of agreement and the safety of catheterization, the caudal ventral artery may be a preferred site for continuous arterial blood pressure monitoring without acute severe hemodynamic changes.

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Transfer of The Rat Tail: An Experimental Model for Free Osteocutaneous Transfer

Cited by 8 publications

References 4 publications

Digit Replantation Practice: A Comparison of Three Rat Models

Digit Replantation Practice: A Comparison of Three Rat Models

Current status of simulation and training models in microsurgery: A systematic review

Correction: Comparison of Invasive Blood Pressure Measurements from the Caudal Ventral Artery and the Femoral Artery in Male Adult SD and Wistar Rats

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