Transfer of zearalenone to the reproductive system of female rainbow trout spawners: A potential risk for aquaculture and fish consumers?

Woźny, Maciej; Obremski, Krzysztof; Zalewski, Tomasz; Mommens, Maren; Łakomiak, Alicja; Brzuzan, Paweł

doi:10.1016/j.fct.2017.07.010

Cited by 9 publications

(10 citation statements)

References 36 publications

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“…Woźny et al . (, ) dedicated significant efforts at understanding the potential of ZEN bioaccumulation in fish, using mainly rainbow trout as a model. The authors found that after feeding rainbow trout with 1,810 μg ZEN kg −1 feed for 71 days, ZEN was found at a concentration of 732.2 μg kg −1 in the intestine, whereas non‐quantifiable levels of ZEN were found in liver and female ovaries.…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

“…In another trial, Woźny et al . () used mature females (1,274 ± 162 g) to study ZEN carry‐over into eggs. Authors found that ZEN is transferred from the gastrointestinal tract to the reproductive system of the fish, depositing ZEN metabolites in the somatic cells of the ovaries rather than in the oocytes.…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

“…However, the levels found in these tissues, with the exception of the intestine and liver (Table , Woźny et al . ), are rather low and do not pose a direct risk to human consumption. In the European Union, the maximum allowable level of ZEN ranges from 20 μg kg −1 for processed cereal‐based foods (excluding processed maize‐based foods) and baby foods for infants and young, to 300 μg kg −1 for unprocessed maize (not for human consumption) (EC ).…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

“…From 2013 to 2015, Woźny et al . () surveyed ovary, oocytes and salted roe samples from different fish species collected directly at hatcheries or bought in supermarkets. The authors analysed the samples for the presence of ZEN, α‐ZEL and β‐ZEL.…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

“…The studies reported by Woźny et al . (, ) are also extremely important and highlight the need for guidance values for the amount of ZEN in aquafeeds for fish health and reproductive performance, but also to avoid carry‐over risk to human consumers.…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

See 4 more Smart Citations

Mycotoxins in aquaculture: feed and food

Gonçalves

Schatzmayr²,

Albalat

et al. 2018

Reviews in Aquaculture

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Mycotoxins, secondary metabolites produced by moulds, are responsible for causing significant economic losses due to spoilage of agricultural products but also due to direct or indirect health impact on livestock upon ingestion of mycotoxin contaminated feedstuffs. Aquaculture farmed species are not an exception and studies reporting mycotoxin‐related issues in the aquaculture industry have been increasing. However, our understanding on the prevalence and impact of mycotoxins in the aquaculture sector is still lower compared to the terrestrial livestock sector. Consequently, regulatory limits and guidance values have been defined based on the studies on terrestrial farm animals. The aim of this review is to compile and critically assess mycotoxin occurrence and co‐occurrence in aquaculture finished feeds, and understand the risk of mycotoxin carry‐over in aquaculture seafood products. Furthermore, we aim with this review to raise awareness to the scientific community, the regulatory authorities and the aquaculture industry to the need for specific aquaculture mycotoxin maximum concentration levels for both aquaculture feeds and foods.

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Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

See 3 more Smart Citations

Mycotoxins in aquaculture: feed and food

Gonçalves

Schatzmayr²,

Albalat

et al. 2018

Reviews in Aquaculture

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Proteomic analysis of zearalenone toxicity on mouse thymic epithelial cells

Geng

Tan

Zhao

et al. 2021

J of Applied Toxicology

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Zearalenone (ZEA) is one of the most major food contaminants in cereal crops worldwide, risking health of both livestock and humans. This study aimed to assess the cytotoxicity and the underlying mechanism of ZEA on thymic epithelial cells. By using proteomics analysis, we identified 596 differentially expressed proteins in MTEC1 cells upon zearalenone exposure, of which 245 were upregulated and 351 were downregulated. Gene ontology (GO) analysis suggested that differentially expressed proteins were participated in protein synthesis, oxidative phosphorylation, and ATP binding. KEGG pathway enrichment analysis showed that differentially expressed proteins were mainly related to mitochndrial metabolism, such as citrate cycle (TCA cycle) and oxidative phosphorylation. We demonstrated that ZEA treatment was able to increase the intracellular reactive oxygen species (ROS) level, to decrease ΔΨm, ATP level, and the copy number of mtDNA, leading to necrotic cell death. Moreover, we showed that ZEA treatment inhibited cell proliferation and induced G2/M phase arrest by downregulation of proliferation‐associated proteins ERK, p‐ERK, CDK1, and p‐CHK1. Taken together, we found that the toxicity of ZEA on thymic epithelial cells is mainly caused by the inhibition of mitochondrial dysfunction and cell proliferation. Our study might open new avenues for treatment strategies.

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Reproductive and Maternal Nutrition in Changing Climatic Conditions

Sandor

2022

Outlook of Climate Change and Fish Nutrition

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Transfer of zearalenone to the reproductive system of female rainbow trout spawners: A potential risk for aquaculture and fish consumers?

Cited by 9 publications

References 36 publications

Mycotoxins in aquaculture: feed and food

Mycotoxins in aquaculture: feed and food

Proteomic analysis of zearalenone toxicity on mouse thymic epithelial cells

Reproductive and Maternal Nutrition in Changing Climatic Conditions

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