2023
DOI: 10.3390/biology12060871
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Transfer RNA Mutation Associated with Type 2 Diabetes Mellitus

Fanny Rizki Rahmadanthi,
Iman Permana Maksum

Abstract: Transfer RNA (tRNA) genes in the mitochondrial DNA genome play an important role in protein synthesis. The 22 tRNA genes carry the amino acid that corresponds to that codon but changes in the genetic code often occur such as gene mutations that impact the formation of adenosine triphosphate (ATP). Insulin secretion does not occur because the mitochondria cannot work optimally. tRNA mutation may also be caused by insulin resistance. In addition, the loss of tRNA modification can cause pancreatic β cell dysfunct… Show more

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