Many countries have started to develop policy programs for the sustainable use of natural resources. Indicators and targets can cover both a territorial and a life-cycle-wide global perspective. This article focuses on how a safe operating space for global material resource use can be outlined based on existing economy-wide material flow indicators. It reflects on issues such as scale and systems perspective, as the choice of indicators determines the target "valves" of the socio-industrial metabolism. It considers environmental pressures and social aspects of safe and fair resource use. Existing proposals for resource consumption targets are reviewed, partially revisited, and taken as a basis to outline potential target values for a safe operating space for the extraction and use of minerals and biomass by final consumption. A potential sustainability corridor is derived with the Total Material Consumption of abiotic resources ranging from 6 to 12 t/person, the Total Material Consumption of biotic resources not exceeding 2 t/person, and the Raw Material Consumption of used biotic and abiotic materials ranging from 3 to 6 t/person until 2050. For policy, a "10-2-5 target triplet" can provide orientation, when the three indicators are assigned values of 10, 2, and 5 t/person, respectively.