The aim of this work was at evaluating the activities related to the pharmaceutical assistance for tuberculosis in Santa Maria, RS, as well as its adequacy to the guidelines from Controlling of Tuberculosis in Brazil Handbook. Strengths and weaknesses from the actions developed of the Division of Tuberculosis throughout a descriptive observational study were identified in this research, from August 2012 to January 2013. It was noticed a meaningful search for the service, which was made by a diagnosis and follow-up of the treatment, using combined doses. Despite the monthly follow-up of the treatment for symptoms and sputum smears, and the adoption of standard procedures in order to reduce dropouts and relapses as the use of incentives, the adherence keeps remaining the biggest challenge. Based on the overview found, it is suggested the implementation of humanized follow-up practices, approaching patients and health professional during the treatment, with the intention of improving the adherence to pharmacotherapy and promoting life quality to the patients.