Transferosomes: A promising vesicular-based skin-oriented drug delivery system

Shende, Madhukar; Bodele, S. B.; Ghode, Shweta; Baravkar, Atul; Nalawade, Nilesh Ashokrao

doi:10.54037/wjps.2021.91009

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“…Sediment was treated with 1 ml of 0.1 % isopropyl alcohol to lyses the vesicle and then diluted to 5 ml with buffer (pH 7.4), and absorbance was taken at 380 nm. The percent entrapment was calculated by using formula 17 .…”

Section: Preparationmentioning

confidence: 99%

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2022

IJPSR

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To study and investigate transfersomes as a transdermal delivery system for the poorly soluble drug, Lornoxicam-loaded transfersomes were prepared with non-ionic surfactants like span 80 and tween 80 by the rotary evaporation-sonication method. Drug & polymer was dissolved in an organic solvent mixture of chloroform and ethanol (1:1, v/v). The outcome of the work is that prepared formulations were characterized for particle size analysis, drug entrapment, optical, phase contrast and transmission electron microscopy, in-vitro drug release through cellophane membrane, and drug release kinetic studies. FTIR studies showed compatibility of the drug with excipients. Based on the entrapment efficiency, drug content and in-vitro release studies, the formulation S2 containing span 80 (4% w/w) was selected for permeation studies through albino mice skin and compared with the pure lornoxicam solution. The cumulative percentage of lornoxicam permeated in all formulations was significantly (p<0.05) higher than the pure drug solution. Parameters like vesicular size, zeta potential, and drug entrapment were evaluated after one month. The study substantiated that the transfersome can be used as a feasible alternative formulation of Lornoxicam with advanced permeation characteristics for transdermal application. INTRODUCTION:Transdermal drug delivery systems (TDDS) offer several potential advantages over conventional methods such as injectable and oral delivery 1 . The main barrier and rate-limiting step for the diffusion of drugs across the skin is provided by the outermost layer of the skin, the stratum corneum (SC) 2 .

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Section: Preparationmentioning

confidence: 99%

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2022

IJPSR

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Transferosomes: A promising vesicular-based skin-oriented drug delivery system

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