Transferrin

Lane, R. S.

doi:10.1007/978-1-4684-2679-3_2

Cited by 3 publications

(2 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tissue distribution (Table IV) looks identical to the radioiron distribution of the uniformly labeled diferric species (Table II). Measurement of the ratio 59Fe:55Fe in tagged tissues of normal and iron-deficient rats (Table V) (21)(22)(23)(24)(25), and alternate possibilities have been suggested. One is that the protein is able to pass iron selectively from its individual sites to site-specific tissues and by differential loading and unloading to direct the flow ofiron (26).…”

Section: Resultsmentioning

confidence: 99%

“…Next, ferrous ammonium sulfate (750 j,g Fe dissolved in 2 ml 0.01 N HCI) was mixed with 75 ,uCi 59Fe (as 59FeSO4, sp act 6-20 ,uCi/,Lg, dissolved in 0.5 M HC1, New England Nuclear, Boston, Mass.) or with 225 ,Ci 55Fe (as 55FeSO4, sp act [20][21][22][23][24][25][26][27][28][29][30] ,uCi/,g, dissolved in 0.5 M HCI) from the same manufacturer. The added iron was sufficient to exceed the transferrin saturation by about 20%, and the final pH was 8.1.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Iron uptake from rat plasma transferrin by rat reticulocytes.

Huebers¹,

Huebers²,

Csiba³

et al. 1978

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Fast and slow rat transferrins were isolated by isoelectric focusing and prepared in their di-and monoferric forms. A comparison of the rates of iron release between fast and slow diferric transferrins and between fast and slow monoferric transferrins when incubated with reticulocytes or injected in vivo showed no significant difference in the behavior of the two isotransferrin species. Reticulocyte uptake of diferric transferrin resulted in the removal of both iron atoms from the transferrin molecule. A twofold greater iron uptake was observed from diferric as compared with monoferric iron, provided reticulocyte receptors were saturated. It is concluded that the two species of transferrin and their individual sites function similarly in their release of iron to tissue receptors.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Iron uptake from rat plasma transferrin by rat reticulocytes.

Huebers¹,

Huebers²,

Csiba³

et al. 1978

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

ESR of Iron Proteins

Smith¹,

Pilbrow²

1980

Biological Magnetic Resonance

View full text Add to dashboard Cite

Transferrin—A Poor Measure of Nutritional Status

Roza

Tuitt

Shizgal

1984

J Parenter Enteral Nutr

View full text Add to dashboard Cite

The present study evaluated the sensitivity and specificity of the serum transferrin concentration as a measure of the nutritional state. Serum transferrin was derived from total iron-binding capacity measurements in 74 patients on 114 occasions and correlated with body composition as measured by multiple isotope dilution. Highly significant correlations (p less than 0.001) existed between serum transferrin and both the body cell mass and the nutritional state as measured by the Nae/Ke ratio. However, the 95% confidence limits about both regressions were wide. The false-positive rate was 60% while the false-negative rate was 31%. Body composition and transferrin were measured before and after 2 wk of total parenteral nutrition in 34 malnourished patients. Eighteen patients restored body cell mass toward normal after 2 wk of total parenteral nutrition while in 16 patients the body cell mass continued to decrease in size, despite 2 wk of total parenteral nutrition. The changes in serum transferrin were not significant over this period of time in either group, despite significant changes in the nutritional state in both groups. The presence of a statistically significant relationship between the serum transferrin concentration and the nutritional state indicates that the serum transferrin concentration accurately reflects a population's nutritional status, and is therefore useful in epidemiologic surveys. However, because of the large variance of the data, as demonstrated by the wide 95% confidence limits, and because of the poor sensitivity and specificity, in an individual patient it is of little value as a measure of the nutritional status.

show abstract

Transferrin

Cited by 3 publications

References 125 publications

Iron uptake from rat plasma transferrin by rat reticulocytes.

Iron uptake from rat plasma transferrin by rat reticulocytes.

ESR of Iron Proteins

Transferrin—A Poor Measure of Nutritional Status

Contact Info

Product

Resources

About