Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation

Zhang, Pengcheng; Hu, Li; Yin, Qi; Zhang, Zhiwen; Feng, Linyin

doi:10.1016/j.jconrel.2012.01.031

Cited by 134 publications

(76 citation statements)

References 35 publications

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“…Nano-carriers enable the preferential delivery of chemotherapeutic agents into the tumor foci due to the enhanced permeability and retention (EPR) [31]. Micelles are of particular interest in tumor applications due to their suitable size, biocompatibility, and hydrophobic core, which is emerging as powerful drug delivery vehicles for loading hydrophobic drugs [32]. Here, we also tried to test whether afatinib-encapsulated polymeric micelles (afatinib/micelles) can increase the therapeutic effect of afatinib in HER2-overexpressed tumors.…”

Section: Introductionmentioning

confidence: 99%

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growthin vitroandin vivo

et al. 2014

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Colorectal cancer (CRC) is known as a common malignant neoplasm worldwide. The role of EGFR/HER2 in CRC is unclear. Afatinib is an irreversible EGFR/HER2 inhibitor. There were few studies of afatinib on CRC. Here, we investigated the protein levels/expressions of HER2 in sera and tumors from CRC patients and the therapeutic effect of afatinib on HER2-overexpressed CRC in vitro and in vivo. The increased HER2 levels were detected in the collected sera and tumors of patients with CRC. The serological HER2 levels were correlated with the tumor HER2 expressions in patients. Afatinib also inhibited the HER2-positive tumor cell growth and caused apoptosis in HER2-overexpressed human colorectal cancer HCT-15 cells but not in low HER2 expressed human gastric cancer MKN45 cells. In vivo study showed that afatinib reduced tumor growth in HER2-overexpressed xenografts. Moreover, afatinib-encapsulated micelles displayed higher cytotoxic activity in HCT-15 cells and were more effective for tumor growth suppression in HCT-15-induced tumor xenografts than afatinib performance alone. Taken together, these findings suggest that higher serum HER2 levels reflect the higher HER2 contents in tumors of CRC patients, and the improved afatinib-encapsulated micelles possess high therapeutic efficacy in HER2-overexpressed CRC in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growthin vitroandin vivo

et al. 2014

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“…Tf has been widely used to target cells overexpressing TfRs. Tf modified polyphosphoester micelles demonstrated stronger anti-glioma activity in mice bearing intracranial U87 MG glioma (Zhang et al 2012). Tf coated gold NPs showed greater uptake in non parenchymal cells than that of lesser uptake in hepatocytes.…”

Section: Targeted Drug Deliverymentioning

confidence: 93%

Nanoscale Materials in Targeted Drug Delivery

Kumari

Singla

Guliani

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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Nanoscale materials (NSMs) are gaining attention due to their small size and unique physiochemical properties. Different approaches are used for the synthesis of NSMs. NSMs cannot be visualized by ordinary instruments. Instruments with high resolution are required for their characterisation. NSMs offer enhanced activity and specificity to encapsulate drugs. NSM are used as vehicles for site specific delivery of drugs inside the body. In this chapter, approaches for the synthesis of NSMs, and characterisation techniques for NSMs like SEM, TEM, AFM, DLS, XRD, and FTIR have been explained briefly. In addition, this chapter also covers zero dimensional one dimensional, two dimensional and three dimensional NSMs briefly. Detailed information about approaches of targeted delivery like passive and active have been covered in this chapter. NSMs like polymeric nanoparticles, metallic nanoparticles, liposomes, quantum dots, polymeric micelles, carbon nanotubes, dendrimers, and magnetic nanoparticles used in targeted drug delivery have also been explained in this chapter.

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“…In addition to PEG-modified PCL NPs, other PCL-based polymers, such as PCL-F68,[112] PCL-PVP,[113] PCL-polyphosphoester,[114] and PCL-PEG-PCL [115], have also been used for PTX delivery. For example, poloxamers was conjugated to PCL because of its capability of sensitizing MDR tumors.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy

Wang

Porter

Konstantopoulos

et al. 2017

Journal of Controlled Release

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136

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Paclitaxel (PTX) is one of the most successful drugs ever used in cancer chemotherapy, acting against a variety of cancer types. Formulating PTX with Cremophor EL and ethanol (Taxol®) realized its clinical potential, but the formulation falls short of expectations due to side effects such as peripheral neuropathy, hypotension, and hypersensitivity. Abraxane®, the albumin bound PTX, represents a superior replacement of Taxol® that mitigates the side effects associated with Cremophor EL. While Abraxane® is now considered a gold standard in chemotherapy, its 21% response rate leaves much room for further improvement. The quest for safer and more effective cancer treatments has led to the development of a plethora of innovative PTX formulations, many of which are currently undergoing clinical trials. In this context, we review recent development of PTX drug delivery systems and analyze the design principles underpinning each delivery strategy. We chose several representative examples to highlight the opportunities and challenges of polymeric systems, lipid-based formulations, as well as prodrug strategies.

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Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation

Cited by 134 publications

References 35 publications

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growthin vitroandin vivo

Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growthin vitroandin vivo

Nanoscale Materials in Targeted Drug Delivery

Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy

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