Transferrin in fishes: A review article

Asmamaw, Berhan

doi:10.12980/jclm.4.2016j5-255

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…This can be ascribed to the disruption of the synthesis of transferrin, a protein that is responsible for binding iron for catalysis. Transferrin is mainly synthesized in the liver and secreted into the plasma (Asmamaw, 2016).…”

Section: Resultsmentioning

confidence: 99%

Sublethal toxicity test of mercury (Hg) in the flesh and tissue of Tilapia (<i>Oreochromis niloticus</i>)

et al. 2020

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This study tested the sublethal toxicity of mercury (Hg) in the flesh and tissue of tilapia (Oreochromis niloticus). This research used an experimental method completely randomized design (CRD) with 3 treatments and 3 replications. The treatments used different Hg concentrations: Treatment A = 0.08 ppm; B = 0.16 ppm; C = 0.24 ppm; and the control group = without the addition of Hg. The parameters observed were the accumulation of mercury (Hg) in the flesh and tissue damage (histopathology) of the gills, kidneys and liver of tilapia. The results showed that the highest Hg accumulation was at the highest Hg concentration (treatment C = 0.24 ppm). Tissue damage was mainly found in the kidneys, liver and gills of fish exposed to Hg with indications of bleeding, tubular necrosis, vacuolization of epithelial cells, and mononuclear cell infiltration. The results showed that the toxicity of mercury to the organs increased with the increase in the concentration of Hg in water. Keywords : flesh, mercury, Oreochromis niloticus, sublethal, tissue

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Section: Resultsmentioning

confidence: 99%

Sublethal toxicity test of mercury (Hg) in the flesh and tissue of Tilapia (<i>Oreochromis niloticus</i>)

et al. 2020

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“…Transferrin is the major protein that transports iron in the body, and therefore plays a role in the homeostasis of iron [24]. Transferrin is synthesized in the liver and under normal physiological conditions, iron in the blood is bound to transferrin [25].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Some Heavy Metals and Iron Parameters amongst Dumpsite Scavengers in Port Harcourt, Nigeria

Godwin

Brown

Nwachuku

2020

JAMPS

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Aim: The aim of the study was to determine the levels of some heavy metals, namely Cadmium (Cd), Lead (Pd), and Iron (Fe) in waste scavengers in port-Harcourt, Nigeria Study Design: This study is a cross-sectional observational study. Place and Duration of Study: This study was conducted in Port Harcourt, Rivers State, Nigeria, between March, 2019 and October, 2019. Methodology: A total of 170 subjects of ages between 16 to 43 years. Of this, 100 were dumpsite scavengers while 70 were apparently healthy control subjects. The subjects involved in this study gave their informed consent and had no history of diabetes mellitus, hypertension, and renal and hepatic disorders, and have been in scavenging activity for at least one year. Three milliliters (3ml) of blood was taken from each subject and put in plain bottles. The serum obtained was put in plain bottles and stored at -200C prior to analysis. The heavy metals were assayed using the Atomic Absorption Spectrophotometry (AAS) while the hepatic parameters were assayed using Mindray Biochemistry auto analyzer (Model BS120, Shenzhen, China). Serum ferritin was assayed using enzyme immunoassay while serum transferrin was done using colorimetric method. Data obtained were analyzed using Student’s t test and Pearson’s correlation. Results: The body mass index (BMI) of the scavengers were significantly lower than that of the control subjects (p=.0001). The activities of the liver enzymes AST, ALT and ALP were significantly higher in the scavengers compared to the control subjects (p=.0001). The levels of total proteins, albumin and globulin of the scavengers were significantly lower than those of the control subjects (p=.0001). The levels of serum iron, transferrin and ferritin were similarly lower in the scavengers compared to the control subjects (p=.0001). However, the levels of cadmium and lead were significantly higher in the scavengers compared to the control subjects (p=.0001). Conclusion: These findings indicate possible biochemical derangements in the scavengers due to their exposure to the hazards associated with the scavenging activity.

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“…For tissues (that is, non-liver tissues) where there is a blood barrier separation between the cells and transferrin in the plasma, transferrin synthesis might become vital. In an ordinary circumstance, transferrin binds most of the blood plasma iron [18].…”

Section: Synthesis Of Transferrinmentioning

confidence: 99%

A Review of Literature on Transferrin: Deciphering its Complex Mechanism in Cellular Iron Regulation and Clinical Implications

Ajayi,

Oladoyinbo

et al. 2024

AJRID

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Iron is a crucial constituent in cellular metabolism, playing a pivotal role in numerous enzymatic activities that are required for the maintenance of life. However, the lack of regulation in iron levels can lead to cellular damage through the Fenton reaction, which produces reactive oxygen species. Transferrin which is a glycoprotein functions crucially in contributing significantly to the movement of iron in biological systems. The polypeptide chain of transferrin, which is made of 700 amino acids, has a crucial role in iron binding and delivery. Transferrin has different N and C lobes that contribute to its exceptional attributes. In this paper, we looked at several aspects of transferrin which were explored, especially its diverse forms, characteristic structures, synthesis mechanisms, and metabolic functions. Various proteins, including lactoferrin, melanotransferrin, serum transferrin, and ovotransferrin, take part in regulating the transportation of iron and the prevention of iron homeostasis in vertebrates. We also explored the role of transferrin in various metabolic processes, which includes its activation of macrophages, antimicrobial attributes, and participation in immunological responses. A detailed assessment of the chemical attributes of transferrin provides useful information about its amino acid constituent, arrangement, and bonds with a broad spectrum of metal ions. This paper delves into taking part in scholarly reviews that address the therapeutic relevance of transferrin, stressing its function as a marker for diagnosing iron deficiency as well as its implications in health conditions such as hemochromatosis and atransferrinemia. This detailed assessment of transferrin that this paper presents makes a renowned development in how we understand its complex mechanisms, thus enhancing how we comprehend iron regulations in cells and how it implies both health and disease.

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Transferrin in fishes: A review article

Cited by 7 publications

References 70 publications

Sublethal toxicity test of mercury (Hg) in the flesh and tissue of Tilapia (<i>Oreochromis niloticus</i>)

Sublethal toxicity test of mercury (Hg) in the flesh and tissue of Tilapia (<i>Oreochromis niloticus</i>)

Assessment of Some Heavy Metals and Iron Parameters amongst Dumpsite Scavengers in Port Harcourt, Nigeria

A Review of Literature on Transferrin: Deciphering its Complex Mechanism in Cellular Iron Regulation and Clinical Implications

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