Transferrin-mediated fullerenes nanoparticles as Fe 2+ -dependent drug vehicles for synergistic anti-tumor efficacy

Zhang, Huijuan; Hou, Lin; Jiao, Xiaojing; Ji, Yandan; Zhu, Xiali; Zhang, Zhenzhong

doi:10.1016/j.biomaterials.2014.10.031

Cited by 90 publications

(59 citation statements)

References 58 publications

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“…The tumor vasculature in the periphery showed a significant contrast enhancement at the initial stage, displaying the accumulation of Gd/SWCNTs-HA-ss-DOX around the tumor tissue by the enhanced permeability and retention effect. 33 Importantly, the tumor interior of Gd/ SWCNTs-HA-ss-DOX exhibited much stronger T 1 contrast enhancements gradually during the time course than Gd/ SWCNTs-COOH, indicating the HA-mediated tumor targeting ability. It was also found that although there was an immediate enhancement in signal intensity for Gd-DTPA group at first 30 minutes, it decreased quickly to the normal level.…”

Section: In Vivo Mrimentioning

confidence: 96%

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

Hou¹,

Yang²,

Ren³

et al. 2016

IJN

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Recently, nanomaterials with multiple functions, such as drug carrier, magnetic resonance imaging (MRI) and optical imaging, and photothermal therapy, have become more and more popular in cancer research. In this work, a novel redox-sensitive system constructed from hyaluronic acid (HA), single-walled carbon nanotubes (SWCNTs), doxorubicin (DOX), and gadolinium (Gd) was successfully developed. Herein, HA-modified SWCNTs (SWCNTs-HA) was first synthesized, and then DOX was conjugated with HA by disulfide bond (SWCNTs-HA-ss-DOX). Finally, MRI contrast agents, Gd 3+ -ion loading occurred through the sidewall defects of SWCNTs, whose cytotoxicity could be sequestered within the SWCNTs. In vitro release of DOX showed that this system accomplished much faster drug release under reducing condition. Confocal microscopy analysis confirmed that Gd/SWCNTs-HA-ss-DOX were capable of simultaneously delivering DOX and SWCNTs into Michigan Cancer Foundation-7 cells via HA receptor-mediated endocytosis followed by rapid transport of cargoes into the cytosol. Enhanced cytotoxicity of Gd/SWCNTs-HA-ss-DOX further proved that the sensitive system was more potent for intracellular drug delivery as compared with the insensitive control. Meanwhile, tumor cell killing potency was improved when Gd/SWCNTs-HA-ss-DOX were combined with near-infrared irradiation, with IC 50 of 0.61 µg/mL at 48 hours. In vivo investigation demonstrated that Gd/SWCNTs-HA-ss-DOX could effectively accumulate in tumor sites and possessed the greatest synergistic antitumor efficacy, especially under the 808 nm laser irradiation. More importantly, this system could be used as a contrast agent for MRI to identify the location and extent of tumor tissues. These results suggested that Gd/SWCNTs-HA-ss-DOX might be a promising system for targeting chemo-photothermal therapy and MRI diagnosis in future clinical anticancer applications.

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Section: In Vivo Mrimentioning

confidence: 96%

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

Hou¹,

Yang²,

Ren³

et al. 2016

IJN

Self Cite

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“…An elegant strategy that has been evaluated in preclinical cancer models is the application of transferrin-artemisinin conjugates as cytotoxic agents232. Artemisinin, discovered and developed by Tu Youyou, for which she was awarded the 2015 Nobel Prize in physiology and medicine, is a drug with antimalarial activity that is isolated from the herb Artemisia annua and contains an intramolecular peroxide bridge.…”

Section: Iron Metabolism As a Therapeutic Targetmentioning

confidence: 99%

“…Fe(II) is involved in the activation of artemisinin by cleavage of this endoperoxide bridge, resulting in the formation of reactive carbon-centred radicals and subsequent cytotoxicity233. By using transferrin as a targeting moiety, both iron and the inactive artemisinin can be delivered to TfR-overexpressing cancer cells; upon internalization of the complex the released Fe(III) is oxidized to Fe(II), which in turn reduces and activates artemisinin into its cytotoxic form232. However, the effect of such artemisinin-constructs on other tissues with high TfR1 expression, notably the bone marrow, has not yet been reported.…”

Section: Iron Metabolism As a Therapeutic Targetmentioning

confidence: 99%

Targeting iron metabolism in drug discovery and delivery

Crielaard

Lammers

Rivella

2017

Nat Rev Drug Discov

290

205

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Iron fulfils a central role in many essential biochemical processes in human physiology, which makes proper processing of iron crucial. Although iron metabolism is subject to relatively strict physiological control, in recent years numerous disorders, such as cancer and neurodegenerative diseases, have been linked to deregulated iron homeostasis. Because of its involvement in the pathogenesis of these diseases, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents will likely have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are often available.

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“…9 To 55 our knowledge, there is only one report about using a multifunctional drug delivery system (HA-C60-Tf) to transport artemisinin derivative (artesunate) for cancer therapy in vivo. 10 Though the therapy result is satisfactory, the dosage of artesunate used in the experiment is still very high. As artesunate is a water 60 soluble derivate, 11 the higher dosage used in this study may be ascribed to the special anticancer mechanism of ART and its derivates instead of the poor water solubility.…”

Section: Introductionmentioning

confidence: 99%

Mn(ii) mediated degradation of artemisinin based on Fe₃O₄@MnSiO₃-FA nanospheres for cancer therapy in vivo

Chen

Zhang

et al. 2015

Nanoscale

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Artemisinin (ART) is a natural drug with potent anticancer activities related with Fe(2+) mediated cleavage of the endoperoxide bridge in ART. Herein, we reported that Mn(2+) could substitute for Fe(2+) to react with ART and generate toxic products, inducing a much higher anticancer efficiency. On this basis, we prepared pH-responsive Fe3O4@MnSiO3-FA nanospheres which can efficiently deliver hydrophobic ART into tumors in mice models. Mn(2+) was released in acidic tumor environments and intracellular lysosomes, interacting with ART to kill cancer cells. The ART-loaded nanocarriers could suppress tumor growth more efficiently than free ART, which could be further illustrated by magnetic resonance imaging (MRI). Histological analysis revealed that the drug delivery system had no obvious effect on the major organs of mice. ART has been reported to have lower toxicity than chemotherapeutics. The ART-loaded nanocarriers are promising to be used in improving the survival of chemotherapy patients, providing a novel method for clinical tumor therapy.

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Transferrin-mediated fullerenes nanoparticles as Fe 2+ -dependent drug vehicles for synergistic anti-tumor efficacy

Cited by 90 publications

References 58 publications

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

Targeting iron metabolism in drug discovery and delivery

Mn(ii) mediated degradation of artemisinin based on Fe₃O₄@MnSiO₃-FA nanospheres for cancer therapy in vivo

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Transferrin-mediated fullerenes nanoparticles as Fe 2+ -dependent drug vehicles for synergistic anti-tumor efficacy

Cited by 90 publications

References 58 publications

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging

Targeting iron metabolism in drug discovery and delivery

Mn(ii) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo

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Mn(ii) mediated degradation of artemisinin based on Fe₃O₄@MnSiO₃-FA nanospheres for cancer therapy in vivo