Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Chen, Wenjie; Xie, Li; Lv, Can; Song, Erqun; Zhu, Xiaolin; Song, Yang

doi:10.1021/acsami.3c01499

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…In a study, the researchers used a TF-targeted cascading nanoplatform Tf-PEG-modified mesoporous polydopamine (MPDA)@artesunate/ML385 (AM) based on mesoporous polydopamine, co-encapsulating the ferroptosis-inducing agent ART and the Nrf2-specific inhibitor ML385. This increased intracellular ROS levels, consequently enhancing ferroptosis ( 49 ). In another study, the investigators developed programmable carriers for ART that respond to enzymes and ROS, adjusting their size and charge to increase stability and overcome challenges associated with solid tumors.…”

Section: Artcsmentioning

confidence: 99%

Natural products targeting ferroptosis pathways in cancer therapy (Review)

Na,

Li,

Liu

et al. 2024

Oncol Rep

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Ferroptosis inducers (FIN) have a key role in cancer therapy and provide novel and innovative treatment strategies. Although many researchers have performed FIN screening of synthetic compounds, studies on the identification of FIN from natural products are limited, particularly in the field of drug development and combination therapy. In this review, this gap was addressed by comprehensively summarizing recent studies on ferroptosis. The causes of ferroptosis were categorized into driving and defensive factors, elucidating key pathways and targets. Next, through summarizing research on natural products that induce ferroptosis, the study elaborated in detail on the natural products that have FIN functions. Their discovery and development were also described and insight for clinical drug development was provided. In addition, the mechanisms of action were analyzed and potential combination therapies, resistance reversal and structural enhancements were presented. By highlighting the potential of natural products in inducing ferroptosis for cancer treatment, this review may serve as a reference for utilizing these compounds against cancer. It not only showed the significance of natural products but may also promote further investigation into their therapeutic effects, thus encouraging research in this field.

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Section: Artcsmentioning

confidence: 99%

Natural products targeting ferroptosis pathways in cancer therapy (Review)

Na,

Li,

Liu

et al. 2024

Oncol Rep

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“…Transferrin (Tf) and transferrin receptor (TfR) form the Tf-TfR complex [ 28 ]. The Tf-TfR complex transfers Fe 3+ into cells, where it is reduced to Fe 2+ [ 29 ].…”

Section: Ferroptosismentioning

confidence: 99%

Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis: A Novel Therapeutic Target in Nervous System Diseases

Tang

Liu

et al. 2023

IJMS

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In recent years, three emerging cell deaths, ferroptosis, necroptosis and pyroptosis, have gradually attracted everyone’s attention, and they also play an important role in the occurrence and development of various diseases. Ferroptosis is an idiographic iron-dependent form regulated cell death with the hallmark of accumulation of the intracellular reactive oxygen species (ROS). Necroptosis is a form of regulated necrotic cell death mediated by the receptor-interacting protein kinase 1(RIPK1) and receptor-interacting protein kinase 3RIPK3. Pyroptosis, also known as cell inflammatory necrosis, is a programmed cell necrosis mediated by Gasdermin D (GSDMD). It is manifested by the continuous swelling of the cells until the cell membrane ruptures, resulting in the release of the cell contents and the activation of a strong inflammatory response. Neurological disorders remain a clinical challenge and patients do not respond well to conventional treatments. Nerve cell death can aggravate the occurrence and development of neurological diseases. This article reviews the specific mechanisms of these three types of cell death and their relationship with neurological diseases and the evidence for the role of the three types of cell death in neurological diseases; understanding these pathways and their mechanisms is helpful for the treatment of neurological diseases.

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Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis

Zhang,

Jiang,

Meng

2024

MRMC

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Since ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis, ROS and lipid peroxide production and metabolism, and a variety of intracellular signaling pathways. Inhibition of ferroptosis is effective in inhibiting the development of atherosclerosis, and it can bring a new direction for treating atherosclerosis. In this review, we discuss the mechanism of ferroptosis and focus on the relationship between ferroptosis and atherosclerosis, summarize the different types of ferroptosis inhibitors that have been widely studied, and discuss some issues worthy of attention in the treatment of atherosclerosis by targeting ferroptosis.

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Transferrin-Targeted Cascade Nanoplatform for Inhibiting Transcription Factor Nuclear Factor Erythroid 2-Related Factor 2 and Enhancing Ferroptosis Anticancer Therapy

Cited by 5 publications

References 47 publications

Natural products targeting ferroptosis pathways in cancer therapy (Review)

Natural products targeting ferroptosis pathways in cancer therapy (Review)

Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis: A Novel Therapeutic Target in Nervous System Diseases

Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis

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