Transfert et échange d'antipyrine dans le lobule placentaire humain perfusé in vitro

A comparative study of the placental transfer to the foetus of three benzodiazepines was performed using a dual perfusion system of the human placental lobule. A transport fraction was calculated for each benzodiazepine and was compared with reference substances. Relative to antipyrine, the transport fraction of diazepam was 85%, and that of nordiazepam was 84%. The transport fraction of clorazepate represented only 20% of that of tritiated water. The relatively high transfer of diazepam and nordiazepam can be attributed to their high lipid solubility, and the lower transfer of clorazepate is due to its polar nature. It is suggested that in certain instances this benzodiazepine may be of especial value to obstetricians.

show abstract

Transfer in vitro of three benzodiazepines across the human placenta

Guerre-Millo

Rey

Challier

et al. 1979

Eur J Clin Pharmacol

View full text Add to dashboard Cite

show abstract

Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta

et al. 2019

View full text Add to dashboard Cite

Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta

Corbel

Gayrard

Puel

et al. 2014

Reproductive Toxicology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Transfert et échange d'antipyrine dans le lobule placentaire humain perfusé in vitro

Abstract: Summary. Antipyrine transfer and exchange in the human placenta lobule during in vitro perfusion. Introduction.

Cited by 5 publications

References 3 publications

Transfer in vitro of three benzodiazepines across the human placenta

Transfer in vitro of three benzodiazepines across the human placenta

Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta

Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta

Contact Info

Product

Resources

About