1970
DOI: 10.1159/000230350
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Transformation of Blood Lymphocytes in Ataxia telangiectasia

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Cited by 9 publications
(8 citation statements)
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“…The response to phytohcmagglutinin of the circulating lymphocytes in Down's syndrome thus resembles that of blood lymphocytes from patients with ataxia-telangiectasia [77] in that both show a marked impairment of the response. However, they differ from each other, in that the optimal dose for maximal response is normal for the major population of lymphocytes in Down's syndrome, in contrast to ataxiatelangiectasia where a shift to a higher dose level is observed, and in which no increased response at low phytohemagglutinin doses occurs.…”
Section: Discussionmentioning
confidence: 91%
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“…The response to phytohcmagglutinin of the circulating lymphocytes in Down's syndrome thus resembles that of blood lymphocytes from patients with ataxia-telangiectasia [77] in that both show a marked impairment of the response. However, they differ from each other, in that the optimal dose for maximal response is normal for the major population of lymphocytes in Down's syndrome, in contrast to ataxiatelangiectasia where a shift to a higher dose level is observed, and in which no increased response at low phytohemagglutinin doses occurs.…”
Section: Discussionmentioning
confidence: 91%
“…It has been further shown that the capacity to manifest delayed hypersensitivity reactions and in vitro lymphoblast transformation of blood lymphocytes by phytohemagglutinin, are due to thymus dependent small lymphocytes [20]. In addition, impaired lymphocyte transformation has been ob served in diseases involving immunological disorders, as in ataxiatelangiectasia [46,68,77], agammaglobulinemia [9], Sjogren's syndrome [47], congenital absence of the thymus [22,44,50] and thymic dysplasia [29,56]. The available evidence strongly indicates that the in vitro lymphocyte transformation is related to the cellular immune reactions, particularly to the delayed hypersensitivity [8,21,29,43,60,69], although a recent report offers evidence indicating that it is related to both cellular and humoral immune reactions [12].…”
Section: Discussionmentioning
confidence: 99%
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“…Lymphocytes from heparinized blood obtained from patients with A-T, were cultured with phytohemagglutinin. A culture time of 72 hr was selected because previous studies had shown that A-T lymphocytes, which typically react poorly to mitogens, respond maximally at about 72 hr and usually provide sufficient metaphases for analysis (11). Cells in metaphase were accumulated by adding colchicine 1.5-2 hr before harvest; they were treated with hypotonic KCl (0.075 M), fixed in methyl alcohol: acetic acid (3: 1), dropped onto glass slides, and air dried.…”
Section: Methodsmentioning
confidence: 99%