Transformation of electrospun Keratin/PVA nanofiber membranes into multilayered 3D Scaffolds: Physiochemical studies and corneal implant applications

Jung, Sunjun; Pant, Bishweshwar; Climans, Megan; Shaw, Gillian C.; Lee, Eunjung; Kim, Namsoo; Park, Soo‐Jin

doi:10.1016/j.ijpharm.2021.121228

Cited by 24 publications

(6 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This material has great potential due to its low toxicity, high water absorption, good mechanical properties (elastic modulus and mechanical strength), biocompatibility, and good physicochemical properties [ 4 , 5 ]. For instance, PVA hydrogel was potentially useful in cartilage tissue substitutes [ 6 ], heart valves [ 7 ], arterial phantoms [ 8 ], corneal implants [ 9 ], electroskins, actuators, supercapacitors, and fuel cells [ 10 , 11 ]. Due to the flexible crosslinking ability, PVA hydrogel was fabricated with different biomolecules and polymers, such as carboxyl methyl cellulose [ 12 ], gelatin, chitosan [ 13 ], graphene oxide [ 14 ], MXene [ 11 ], lignin-silver hybrid nanoparticles [ 15 ], agar [ 16 ], and laponite [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Elango

Zamora‐Ledezma

Negrete-Bolagay

et al. 2022

IJMS

View full text Add to dashboard Cite

Polyvinyl alcohol (PVA) hydrogels are well-known biomimetic 3D systems for mammalian cell cultures to mimic native tissues. Recently, several biomolecules were intended for use in PVA hydrogels to improve their biological properties. However, retinol, an important biomolecule, has not been combined with a PVA hydrogel for culturing bone marrow mesenchymal stem (BMMS) cells. Thus, for the first time, the effect of retinol on the physicochemical, antimicrobial, and cell proliferative properties of a PVA hydrogel was investigated. The ability of protein (3.15 nm) and mineral adsorption (4.8 mg/mL) of a PVA hydrogel was improved by 0.5 wt.% retinol. The antimicrobial effect of hydrogel was more significant in S. aureus (39.3 mm) than in E. coli (14.6 mm), and the effect was improved by increasing the retinol concentration. The BMMS cell proliferation was more upregulated in retinol-loaded PVA hydrogel than in the control at 7 days. We demonstrate that the respective in vitro degradation rate of retinol-loaded PVA hydrogels (RPH) (75–78% degradation) may promote both antibacterial and cellular proliferation. Interestingly, the incorporation of retinol did not affect the cell-loading capacity of PVA hydrogel. Accordingly, the fabricated PVA retinol hydrogel proved its compatibility in a stem cell culture and could be a potential biomaterial for tissue regeneration.

show abstract

Section: Introductionmentioning

confidence: 99%

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Elango

Zamora‐Ledezma

Negrete-Bolagay

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…As for the crystalline domains generated by the annealing, they are effective and strong physical cross-links that require more energy to be destroyed than the single polymer chain, which can redistribute the stress, greatly impede the crack propagation, and thus rendering the hydrogel tougher and stronger. Besides, we compared FDA-SNF/PVA with other strong PVA hydrogels [25,33,40,[50][51][52][53][54][55][56][57][58][59][60][61][62] reported in the literature regarding their tensile strength, tensile strain, toughness, and elastic modulus (Table S1, Supporting Information and Figure 6d-f). Apparently, FDA-SNF/PVA exhibits better tensile strength and tensile strain (Figure 6d).…”

Section: Triple Toughening Mechanism Of Fda-snf/pvamentioning

confidence: 99%

Triple‐Mechanism Enhanced Flexible SiO₂ Nanofiber Composite Hydrogel with High Stiffness and Toughness for Cartilaginous Ligaments

Ma,

Gong,

et al. 2024

Small

View full text Add to dashboard Cite

Hydrogels are widely used in tissue engineering, soft robotics and wearable electronics. However, it is difficult to achieve both the required toughness and stiffness, which severely hampers their application as load‐bearing materials. This study presents a strategy to develop a hard and tough composite hydrogel. Herein, flexible SiO2 nanofibers (SNF) are dispersed homogeneously in a polyvinyl alcohol (PVA) matrix using the synergistic effect of freeze‐drying and annealing through the phase separation, the modulation of macromolecular chain movement and the promotion of macromolecular crystallization. When the stress is applied, the strong molecular interaction between PVA and SNF effectively disperses the load damage to the substrate. Freeze‐dried and annealed‐flexible SiO2 nanofibers/polyvinyl alcohol (FDA‐SNF/PVA) reaches a preferred balance between enhanced stiffness (13.71 ± 0.28 MPa) and toughness (9.9 ± 0.4 MJ m−3). Besides, FDA‐SNF/PVA hydrogel has a high tensile strength of 7.84 ± 0.10 MPa, super elasticity (no plastic deformation under 100 cycles of stretching), fast deformation recovery ability and excellent mechanical properties that are superior to the other tough PVA hydrogels, providing an effective way to optimize the mechanical properties of hydrogels for potential applications in artificial tendons and ligaments.

show abstract

“…Good pore connectivity allows the effective transport of nutrients, oxygen, and metabolic waste products to and from cells [ 33 , 34 ]. The biocompatibility and biodegradability provide a good environment for cell adherence, differentiation, and proliferation, thereby widening the applications of electrospun nanofibers in biomedical fields such as wound dressing [ 30 , 35 ], tissue scaffolds [ 36 ], drug delivery [ 13 ], cosmetics [ 37 ], implants [ 38 ], biosensor [ 39 , 40 ], antibacterial agent [ 16 , 41 ], etc. A schematic diagram showing some potential biomedical applications of electrospun nanofibers is given in Figure 2 A.…”

Section: Biomedical Applications Of Electrospun Nanofibersmentioning

confidence: 99%

Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress

2023

Self Cite

View full text Add to dashboard Cite

Dural defects are a common problem in neurosurgical procedures and should be repaired to avoid complications such as cerebrospinal fluid leakage, brain swelling, epilepsy, intracranial infection, and so on. Various types of dural substitutes have been prepared and used for the treatment of dural defects. In recent years, electrospun nanofibers have been applied for various biomedical applications, including dural regeneration, due to their interesting properties such as a large surface area to volume ratio, porosity, superior mechanical properties, ease of surface modification, and, most importantly, similarity with the extracellular matrix (ECM). Despite continuous efforts, the development of suitable dura mater substrates has had limited success. This review summarizes the investigation and development of electrospun nanofibers with particular emphasis on dura mater regeneration. The objective of this mini-review article is to give readers a quick overview of the recent advances in electrospinning for dura mater repair.

show abstract

Transformation of electrospun Keratin/PVA nanofiber membranes into multilayered 3D Scaffolds: Physiochemical studies and corneal implant applications

Cited by 24 publications

References 62 publications

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Triple‐Mechanism Enhanced Flexible SiO₂ Nanofiber Composite Hydrogel with High Stiffness and Toughness for Cartilaginous Ligaments

Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress

Contact Info

Product

Resources

About

Transformation of electrospun Keratin/PVA nanofiber membranes into multilayered 3D Scaffolds: Physiochemical studies and corneal implant applications

Cited by 24 publications

References 62 publications

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Retinol-Loaded Poly(vinyl alcohol)-Based Hydrogels as Suitable Biomaterials with Antimicrobial Properties for the Proliferation of Mesenchymal Stem Cells

Triple‐Mechanism Enhanced Flexible SiO2 Nanofiber Composite Hydrogel with High Stiffness and Toughness for Cartilaginous Ligaments

Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress

Contact Info

Product

Resources

About

Triple‐Mechanism Enhanced Flexible SiO₂ Nanofiber Composite Hydrogel with High Stiffness and Toughness for Cartilaginous Ligaments