Transformation of Follicular Lymphoma to Leukemic Phase of Burkitt Lymphoma

Chekol, Seble; Kimball, Amy; Ning, Yi; Nanaji, Nahid

doi:10.1093/ajcp/138.suppl1.206

Cited by 1 publication

(3 citation statements)

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“…Further testing with FISH analysis allowed us to confirm the diagnosis and rule out other possibilities, such as mantle cell lymphoma (MCL) in a leukemic phase, chronic lymphocytic leukemia (CLL), and high‐grade B‐cell lymphomas. 9 , 10 Flow cytometry revealed that these lymphoid cells had an immunophenotype characteristic of follicular lymphoma. It is worth noting that lack of CD10 expression cannot exclude the possibility of leukemic phase FL, as reported by Maeshima et al 11 , 12 …”

Section: Discussionmentioning

confidence: 99%

“…Initially, the unusual appearance of the lymphoid cells and the patient's young age made it difficult to diagnose. Further testing with FISH analysis allowed us to confirm the diagnosis and rule out other possibilities, such as mantle cell lymphoma (MCL) in a leukemic phase, chronic lymphocytic leukemia (CLL), and high‐grade B‐cell lymphomas 9,10 . Flow cytometry revealed that these lymphoid cells had an immunophenotype characteristic of follicular lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…4 other possibilities, such as mantle cell lymphoma (MCL) in a leukemic phase, chronic lymphocytic leukemia (CLL), and high-grade B-cell lymphomas. 9,10 Flow cytometry revealed that these lymphoid cells had an immunophenotype characteristic of follicular lymphoma. It is worth noting that lack of CD10 expression cannot exclude the possibility of leukemic phase FL, as reported by Maeshima et al 11,12 Studies have shown that high-risk FLIPI and leukemic phase are associated with shorter progression-free survival (PFS) in patients with follicular lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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Leukemic phase follicular lymphoma in a young adult

Rivera

Wang

Aljumaili

et al. 2023

Clinical Laboratory Analysis

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Background Leukemic presentation of follicular lymphoma (FL) is uncommon, with most cases reported in older adults. Design This report describes an unusual case of a young adult diagnosed with leukemic phase of FL. We reviewed the existing literature on this rare presentation of the disease and its potential impact on patient outcomes. Results Leukemic phase of FL in young adults can be mistaken for other high‐grade hematologic malignancies. Morphology assessment and ancillary testing, such as flow cytometry and FISH analysis, can assist in achieving an accurate diagnosis of the leukemic phase of FL. Notably, our young patient responded well to therapy, which is different from what is typically observed in older patients who have a poorer prognosis. Further cases are needed to investigate the prognostic impact of the leukemic phase of FL in younger patients.

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