Transformation of Human Lymphocytes by Haemophilus influenzae Somatic and Polysaccharide Antigens

Alford, Robert H.

doi:10.3181/00379727-143-37414

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1974

1976

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Cited by 3 publications

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Response of human thymus‐derived (T) and non‐thymus‐derived (B) lymphocytes to mitogenic stimulation in vitro

Geha

Merler

1974

Eur J Immunol

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Highly pure populations of human T and B lymphocytes were prepared from tonsils using a two‐step fractionation procedure. Cells were first fractionated on discontinuous gradients of bovine serum albumin, then separated on the basis of their reactivity with the sheep red cell intermediates, E and EACl423. More than 95 % of the cells in the final suspensions were either T or B lymphocytes. Phytohemagglutinin and concanavalin A were mitogenic exclusively for T cells. Pokeweed was mitogenic for both T and B cells. T cell proliferation occurred in response to two antigens to which the cell donors were immune: tetanus toxoid (TT) and polyribosephosphate (PRP) capsular antigen of Hemophilus influenzae, type b. B lymphocytes did not transform in response to either PRP, soluble TT, or insoluble TT, but transformed vigorously in the presence of supernatants obtained from TT‐activated T cells.

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Response of human thymus‐derived (T) and non‐thymus‐derived (B) lymphocytes to mitogenic stimulation in vitro

Geha

Merler

1974

Eur J Immunol

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Immunologic defense in bacterial and viral meningitis in children

Ströder

Seger

1976

Eur J Pediatr

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The investigation of a number of parameters of nonspecific and specific defense in 13 purulent and 18 mumps meningitides gave no indication of underlying primary immunodeficiencies. Only in the acute phase of mumps meningitis did we find a temporary suppression of cellular immune reactions measured as diminished rate of incorporation of thymidine by phytohemagglutinin-stimulated peripheral blood lymphocytes.

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Comparison of cellular and humoral immune responses to rabies and Sindbis virus in mice

Hill

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Transformation of Human Lymphocytes by Haemophilus influenzae Somatic and Polysaccharide Antigens

Abstract: Cell-mediated immune reactions directed against Haemophilus influenzae antigens include delayed-type skin test reactivity ( 1 ) , and in vitro transformation of human lympho-

Cited by 3 publications

References 5 publications

Response of human thymus‐derived (T) and non‐thymus‐derived (B) lymphocytes to mitogenic stimulation in vitro

Response of human thymus‐derived (T) and non‐thymus‐derived (B) lymphocytes to mitogenic stimulation in vitro

Immunologic defense in bacterial and viral meningitis in children

Comparison of cellular and humoral immune responses to rabies and Sindbis virus in mice

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