Transformation of Monohydrate into Anhydrous Form of Risedronate Monosodium in Methanol−Water Mixture

Abstract

The transformation of a monohydrate into an anhydrous form of risedronate monosodium (RS) in a methanol and water mixture was investigated. The phase transformation was detected by monitoring the number of particles, particle size, and shape. At the same time, polymorphic forms of crystals were identified by various offline techniques such as XRPD, TGA, and DSC. The kinetics of phase transformation was found to be controlled by three-dimensional nuclear growth. The reaction of water in the solvent mixture was a main factor determining the stability of anhydrate and monohydrate forms. The time required for phase transformation was strongly affected by temperature and agitation rate. The phase transformation could be successfully determined in real time by using an in situ particle measurement system.

Simple azo‐based salicylaldimine as colorimetric and fluorescent probe for detecting anions in semi‐aqueous medium

“…The construction of chemical sensor toward various anions (Suksai and Tuntulani, 2003) is an extensive area in the field of supra molecular chemistry (Gale et al, 2008;Gale and Quesada, 2006) due to their vital roles in biological system and environmental and clinical applications. Anions play an important role in a wide range of industrial (Lehn, 1985;Hijji et al, 2009;Zuhair et al, 2006) and biological processes (Nguyen and Kim, 2009;Mizuno et al, 2002;Yu et al, 2007;Beer and Gale, 2001), and considerable attention has been focused for the recognition of anion species selectively through visible, electrochemical, and optical responses. Among all anions, fluoride and acetate are of particular interest because of their wide range of biological and environmental application.…”

Solid‐State and Solution‐Mediated Polymorphic Transformation of Rifampicin

“…Polymorphic transformation processes can be studied by different analytical equipment, such as FTIR, focused-beam reflectance measurement (FBRM), particle video microscope (PVM) [17], Raman spectroscopy, PXRD [18][19][20][21][22], and so on. In this study, FTIR and PXRD were applied in SMT and SST studies separately.…”

Determination of Water Content in THF Based on Chemical Shift Differences in Solution NMR

“…1 The traditional technique to measure water content in solvents is Karl Fischer titration. 2 Other methods such as chromatography, 3,4 infrared spectroscopy, 5,6 and electrochemistry 7 have also been used.…”

“…Based on the prominent chromogenic behaviors induced by hydrogen bonding interactions, the chemical shift variations of the dye-F systems were systematically measured as a function of water content in THF using 1 H NMR. Figure 2 shows the 1 H NMR spectral changes in the aromatic proton region of 1-F and 2-F systems with increasing water content up to 5 and 30%, respectively.…”

“…In conclusion, in this study, 1 H NMR chemical shift differences were used as a probe for water content in organic solvents. Changes in chemical shift differences reflecting the competition for hydrogen bondings between fluoride ions and water were linearly proportional to water content within certain ranges.…”