Transformation of organic compounds by microbial enzymes

Tamm, Christoph

doi:10.1016/0014-5793(74)81052-5

Cited by 10 publications

(5 citation statements)

References 52 publications

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“…A likely mechanism for the initial increase in the unsaturated oleic acid is the dehydrogenation of stearic to oleic acid due to an oxidation process produced by microbial enzymes present in the early post-mortem stage. This mechanism was established in earlier experimental studies where stearic acid was converted to oleic acid using Corynebacterium diphteriae [15,16]. Further support for this mechanism in the current study is provided by monitoring the change to the stearic acid concentrations over the lifetime of the seasonal trials.…”

Section: Winter Trialsupporting

confidence: 76%

Seasonal variation of fatty acid profiles from textiles associated with decomposing pig remains in a temperate Australian environment

2018

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A methodology to examine the human post-mortem decomposition process has been developed through the monitoring of chemical changes to decomposition fluids absorbed by clothing. Model surface deposition using clothed pigs were established during summer and winter seasons in a temperate region of Australia. Three clothing materials were investigated: cotton, polyester and cotton-polyester. Lipid decomposition products were extracted from the textiles and the fatty acid composition measured as a function of surface deposition time using gas chromatographymass spectrometry (GC-MS). Two derivatisation methods for the fatty acids were compared to establish the most effective approach and it was established that a trimethylsilylation derivatisation method is the optimal preparation technique. The summer trials revealed two rates of transformation of fatty acids from unsaturated to saturated forms, with a faster rate of change occurring earlier in the trials. A different pattern of behaviour was observed for the fatty acids detected during the winter trial, with a decrease in saturated fatty acids initially observed, followed by the conversion of unsaturated to saturated fatty acids until the end of trial. The initial change observed during the winter trial was attributed to a dehydrogenation process caused by microbiological enzymatic activity. The study has demonstrated the feasibility of examining lipid decomposition products collected in clothing from surface depositions to provide insight into the conditions and length of deposition.

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Section: Winter Trialsupporting

confidence: 76%

Seasonal variation of fatty acid profiles from textiles associated with decomposing pig remains in a temperate Australian environment

2018

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“…That fact together with the 4-allyl group make those compounds maintain the inhibitory capacity of colony growing. Furthermore, the ester compounds could be hydrolyzed by intracellular microbial enzymes, 25 thus generating intracellular eugenol.…”

Section: Resultsmentioning

confidence: 99%

Intrinsically Antibacterial Materials Based on Polymeric Derivatives of Eugenol for Biomedical Applications

et al. 2008

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Infections are the most common cause of biomaterial implant failure representing a constant challenge to the more widespread application of medical implants. This study reports on the preparation and characterization of novel hydrophilic copolymeric systems provided with antibacterial properties coming from eugenol residues anchored to the macromolecular chains. Thus, high conversion copolymers were prepared from the hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA) and different eugenol monomeric derivatives, eugenyl methacrylate (EgMA) and ethoxyeugenyl methacrylate (EEgMA), by bulk polymerization reaction. Thermal evaluation revealed glass transition temperature values in the range 95-58 degrees C following the order HEMA-co-EgMA > PHEMA > HEMA-co-EEgMA and a clear increase in thermal stability with the presence of any eugenyl monomer in the system. In vitro wettability studies showed a reduction of water sorption capacity and surface free energy values with increasing the content of eugenol residues in the copolymer. The antimicrobial activity of copolymeric discs was evaluated by determining their capacity to reduce or inhibit colony formation by different bacterial species. All eugenyl containing materials showed bacteria growth inhibition, this one being higher for the EEgMA derivative copolymers.

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“…This structural element is a possible target of the enzyme 1 -SDH for the 1,2-dehydrogenation ( Fig. 1) [14,15]. The products resulting from such transformations of cortisol and cortisone are prednisolone and prednisone, respectively.…”

Section: Introductionmentioning

confidence: 99%

Investigations of the microbial transformation of cortisol to prednisolone in urine samples

Bredehöft

Baginski

Parr

et al. 2012

The Journal of Steroid Biochemistry and Molecular Biology

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Transformation of organic compounds by microbial enzymes

Cited by 10 publications

References 52 publications

Seasonal variation of fatty acid profiles from textiles associated with decomposing pig remains in a temperate Australian environment

Seasonal variation of fatty acid profiles from textiles associated with decomposing pig remains in a temperate Australian environment

Intrinsically Antibacterial Materials Based on Polymeric Derivatives of Eugenol for Biomedical Applications

Investigations of the microbial transformation of cortisol to prednisolone in urine samples

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